Version history

{
  "scope": "anesthetized mouse S1, two-photon-targeted multi-cell (2–4) whole-cell patch-clamp recording across L1–L3",
  "claim_text": "Two-photon-targeted multiple (2–4) whole-cell patch-clamp recording in anesthetized mouse S1 enables detection of monosynaptically connected neuron pairs across superficial layers 1–3 — providing a generalized in vivo method for measuring intracortical excitatory connection probabilities and unitary EPSPs across translaminar pairs at distances <150 μm.",
  "raw_fields": {
    "n": 0,
    "doi": "10.3389/fnsyn.2019.00015",
    "claim": "Two-photon-targeted multiple (2–4) whole-cell patch-clamp recording in anesthetized mouse S1 enables detection of monosynaptically connected neuron pairs across superficial layers 1–3 — providing a generalized in vivo method for measuring intracortical excitatory connection probabilities and unitary EPSPs across translaminar pairs at distances <150 μm.",
    "cite_key": "Jouhanneau2019",
    "evidence": "Anesthetized mouse S1; two-photon-guided multiple (2–4) whole-cell patch-clamp recording from nearby neurons in cortical L1–L3; method validated on monosynaptically connected pairs.",
    "effect_size": "<150 μm pair distance; 2–4 simultaneous patches.",
    "text_access": "abstract_only",
    "study_system": "anesthetized mouse S1, two-photon-targeted multi-cell (2–4) whole-cell patch-clamp recording across L1–L3",
    "argument_role": "supporting",
    "replication_status": "methods_validation",
    "claim_source_sentence": "To address this, we have developed two-photon targeted multiple (2-4) whole-cell patch clamp recordings of nearby neurons in superficial cortical layers 1-3. Here, we describe a step-by-step guide to this approach in the anesthetized mouse primary somatosensory cortex.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [
      "10.1016/j.neuron.2014.11.025"
    ],
    "effect_size_source_sentence": null
  },
  "section_id": "section_04",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "effect_size": "<150 μm pair distance; 2–4 simultaneous patches.",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "source_kind": "review_finding",
  "source_path": "evidence/section_04_evidence_package.json",
  "source_refs": [
    "paper:paper-47adc87cd10d"
  ],
  "source_span": "To address this, we have developed two-photon targeted multiple (2-4) whole-cell patch clamp recordings of nearby neurons in superficial cortical layers 1-3. Here, we describe a step-by-step guide to this approach in the anesthetized mouse primary somatosensory cortex.",
  "study_system": "anesthetized mouse S1, two-photon-targeted multi-cell (2–4) whole-cell patch-clamp recording across L1–L3",
  "evidence_refs": [
    {
      "ref": "paper:paper-47adc87cd10d"
    }
  ],
  "section_title": "4. Translaminar excitatory loops in mouse — L4→L2/3→L5→L6→L4 within the column; asymmetry of forward and backward intracortical projections",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Anesthetized mouse S1; two-photon-guided multiple (2–4) whole-cell patch-clamp recording from nearby neurons in cortical L1–L3; method validated on monosynaptically connected pairs.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "methods_validation",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}