- claim_text
Two-photon-targeted multiple (2–4) whole-cell patch-clamp recording in anesthetized mouse S1 enables detection of monosynaptically connected neuron pairs across superficial layers 1–3 — providing a generalized in vivo method for measuring intracortical excitatory connection probabilities and unitary EPSPs across translaminar pairs at distances <150 μm.
- raw_fields
{
"n": 0,
"doi": "10.3389/fnsyn.2019.00015",
"claim": "Two-photon-targeted multiple (2–4) whole-cell patch-clamp recording in anesthetized mouse S1 enables detection of monosynaptically connected neuron pairs across superficial layers 1–3 — providing a generalized in vivo method for measuring intracortical excitatory connection probabilities and unitary EPSPs across translaminar pairs at distances <150 μm.",
"cite_key": "Jouhanneau2019",
"evidence": "Anesthetized mouse S1; two-photon-guided multiple (2–4) whole-cell patch-clamp recording from nearby neurons in cortical L1–L3; method validated on monosynaptically connected pairs.",
"effect_size": "<150 μm pair distance; 2–4 simultaneous patches.",
"text_access": "abstract_only",
"study_system": "anesthetized mouse S1, two-photon-targeted multi-cell (2–4) whole-cell patch-clamp recording across L1–L3",
"argument_role": "supporting",
"replication_status": "methods_validation",
"claim_source_sentence": "To address this, we have developed two-photon targeted multiple (2-4) whole-cell patch clamp recordings of nearby neurons in superficial cortical layers 1-3. Here, we describe a step-by-step guide to this approach in the anesthetized mouse primary somatosensory cortex.",
"source_provenance_status": "non_substring_match",
"replication_evidence_dois": [
"10.1016/j.neuron.2014.11.025"
],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-47adc87cd10d"
]
- source_span
To address this, we have developed two-photon targeted multiple (2-4) whole-cell patch clamp recordings of nearby neurons in superficial cortical layers 1-3. Here, we describe a step-by-step guide to this approach in the anesthetized mouse primary somatosensory cortex.
- evidence_refs
[
{
"ref": "paper:paper-47adc87cd10d"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}