- claim_text
VIP interneurons in mouse somatosensory cortex mature postnatally with subtype-asymmetric synaptic ontogenesis: mEPSC frequency rises before P8-10 (excitatory innervation first), mIPSC frequency rises by P14-16 (delayed inhibitory integration), and the E/I charge-transfer ratio remains constant across development; synaptic kinetics accelerate while presynaptic release probability decreases by adulthood.
- raw_fields
{
"n": null,
"doi": "10.1111/apha.14265",
"claim": "VIP interneurons in mouse somatosensory cortex mature postnatally with subtype-asymmetric synaptic ontogenesis: mEPSC frequency rises before P8-10 (excitatory innervation first), mIPSC frequency rises by P14-16 (delayed inhibitory integration), and the E/I charge-transfer ratio remains constant across development; synaptic kinetics accelerate while presynaptic release probability decreases by adulthood.",
"title": null,
"cite_key": "Simacek2025b",
"evidence": "Patch-clamp electrophysiology of VIP-INs in Vip-IRES-cre × tdTomato mouse somatosensory cortex at P3-4, P8-10, P14-16, P30-36.",
"effect_size": null,
"text_access": "abstract_only",
"study_system": "mouse S1 cortex; Vip-IRES-Cre × tdTomato; ex vivo patch-clamp",
"target_section": "section_03",
"_source_cluster": "cluster_01_molecular_taxonomy",
"replication_status": "replication_unknown",
"_source_cluster_index": 118,
"claim_source_sentence": "mEPSC frequency increased before P8-10, while mIPSC frequency increased at P14-16. Only mIPSC kinetics became accelerated, and the E/I ratio of synaptic inputs, defined as a ratio of mEPSC to mIPSC charge transfer, remained constant throughout the investigated developmental stages.",
"replication_evidence_dois": [],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-b709c20d2cb8"
]
- source_span
mEPSC frequency increased before P8-10, while mIPSC frequency increased at P14-16. Only mIPSC kinetics became accelerated, and the E/I ratio of synaptic inputs, defined as a ratio of mEPSC to mIPSC charge transfer, remained constant throughout the investigated developmental stages.
- evidence_refs
[
{
"ref": "paper:paper-b709c20d2cb8"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}