Version history

{
  "scope": "Awake head-fixed mouse; multi-slice fUS imaging through intact skull",
  "claim_text": "Simultaneous multi-slice functional-ultrasound imaging can map brain-wide hemodynamic functional networks in awake mice through intact skull, but its single-trial blood-volume readout (>10% increase during visual stimulation) does not resolve single neurons — illustrating the resolution gap between mesoscale-FC and cellular E→E approaches.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1162/imag_a_00030",
    "claim": "Simultaneous multi-slice functional-ultrasound imaging can map brain-wide hemodynamic functional networks in awake mice through intact skull, but its single-trial blood-volume readout (>10% increase during visual stimulation) does not resolve single neurons — illustrating the resolution gap between mesoscale-FC and cellular E→E approaches.",
    "cite_key": "Bertolo2023",
    "evidence": "Quantifies the mesoscale hemodynamic-imaging baseline that frames what Neuropixels and voltage imaging contribute differently.",
    "effect_size": ">10% CBV increase during visual stimulation vs baseline",
    "text_access": "abstract_only",
    "study_system": "Awake head-fixed mouse; multi-slice fUS imaging through intact skull",
    "argument_role": "supporting",
    "replication_status": "single-study",
    "claim_source_sentence": "Significant activation was detected along the whole visual pathway, at both single and group levels, with more than 10% of augmentation of the cerebral blood volume (CBV) signal during the visual stimulation compared to baseline.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Significant activation was detected along the whole visual pathway, at both single and group levels, with more than 10% of augmentation of the cerebral blood volume (CBV) signal during the visual stimulation compared to baseline."
  },
  "section_id": "section_16",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_16_evidence_package.json",
  "effect_size": ">10% CBV increase during visual stimulation vs baseline",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-16-synthesis",
  "source_kind": "review_finding",
  "source_path": "evidence/section_16_evidence_package.json",
  "source_refs": [
    "paper:paper-7bd9a028fc66"
  ],
  "source_span": "Significant activation was detected along the whole visual pathway, at both single and group levels, with more than 10% of augmentation of the cerebral blood volume (CBV) signal during the visual stimulation compared to baseline.",
  "study_system": "Awake head-fixed mouse; multi-slice fUS imaging through intact skull",
  "evidence_refs": [
    {
      "ref": "paper:paper-7bd9a028fc66"
    }
  ],
  "section_title": "16. Synthesis — which computational claims the mouse-cortex E→E empirical record actually supports, where the bottleneck observations are, and what an inhibition-free, single-species, basic-research analytic framing misses",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Quantifies the mesoscale hemodynamic-imaging baseline that frames what Neuropixels and voltage imaging contribute differently.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "single-study",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-16-synthesis",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_16_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}