- claim_text
Kv3.1b and Kv3.2 expression in developing cortical interneurons is differentially controlled by neuronal activity and neurotrophic factors: chronic activity deprivation reduces both mRNAs, while BDNF and NT4 selectively increase Kv3.1b but not Kv3.2 mRNA.
- raw_fields
{
"n": 0,
"doi": "10.1016/j.neuroscience.2008.08.008",
"claim": "Kv3.1b and Kv3.2 expression in developing cortical interneurons is differentially controlled by neuronal activity and neurotrophic factors: chronic activity deprivation reduces both mRNAs, while BDNF and NT4 selectively increase Kv3.1b but not Kv3.2 mRNA.",
"evidence": "Organotypic cultures of rat visual cortex treated with activity blockers (TTX, glutamate receptor antagonists) or neurotrophins. Activity deprivation from 10-20 DIV reduced both Kv3.1b and Kv3.2 mRNAs.",
"effect_size": "BDNF/NT4 increase Kv3.1b but not Kv3.2 mRNA; TTX reduces both mRNAs and Kv3.2 protein",
"text_access": "abstract_only",
"study_system": "rat visual cortex organotypic cultures",
"replication_status": "replication_unknown",
"claim_source_sentence": "The results show that Kv3.1b/3.2 expression is differentially controlled by neuronal activity and neurotrophic factors.",
"replication_evidence_dois": [],
"effect_size_source_sentence": "BDNF and NT4 supplemented from 2 DIV onwards increased the expression of Kv3.1b, but not Kv3.2 mRNA in young cultures."
}- source_refs
[
"paper:paper-7037b818c0ba"
]
- evidence_refs
[
{
"ref": "paper:paper-7037b818c0ba"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}