Version history

{
  "scope": "rat visual cortex organotypic cultures",
  "claim_text": "Kv3.1b and Kv3.2 expression in developing cortical interneurons is differentially controlled by neuronal activity and neurotrophic factors: chronic activity deprivation reduces both mRNAs, while BDNF and NT4 selectively increase Kv3.1b but not Kv3.2 mRNA.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1016/j.neuroscience.2008.08.008",
    "claim": "Kv3.1b and Kv3.2 expression in developing cortical interneurons is differentially controlled by neuronal activity and neurotrophic factors: chronic activity deprivation reduces both mRNAs, while BDNF and NT4 selectively increase Kv3.1b but not Kv3.2 mRNA.",
    "evidence": "Organotypic cultures of rat visual cortex treated with activity blockers (TTX, glutamate receptor antagonists) or neurotrophins. Activity deprivation from 10-20 DIV reduced both Kv3.1b and Kv3.2 mRNAs.",
    "effect_size": "BDNF/NT4 increase Kv3.1b but not Kv3.2 mRNA; TTX reduces both mRNAs and Kv3.2 protein",
    "text_access": "abstract_only",
    "study_system": "rat visual cortex organotypic cultures",
    "replication_status": "replication_unknown",
    "claim_source_sentence": "The results show that Kv3.1b/3.2 expression is differentially controlled by neuronal activity and neurotrophic factors.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "BDNF and NT4 supplemented from 2 DIV onwards increased the expression of Kv3.1b, but not Kv3.2 mRNA in young cultures."
  },
  "section_id": "section_05_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_05_evidence_package.json",
  "effect_size": "BDNF/NT4 increase Kv3.1b but not Kv3.2 mRNA; TTX reduces both mRNAs and Kv3.2 protein",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-05",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-7037b818c0ba"
  ],
  "source_span": "The results show that Kv3.1b/3.2 expression is differentially controlled by neuronal activity and neurotrophic factors.",
  "study_system": "rat visual cortex organotypic cultures",
  "evidence_refs": [
    {
      "ref": "paper:paper-7037b818c0ba"
    }
  ],
  "section_title": "Intrinsic Electrophysiology: The Fast-Spiking Phenotype and Its Variants",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "evidence_summary": "Organotypic cultures of rat visual cortex treated with activity blockers (TTX, glutamate receptor antagonists) or neurotrophins. Activity deprivation from 10-20 DIV reduced both Kv3.1b and Kv3.2 mRNAs.",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-e6261c8263e7",
  "source_artifact_ref": "wiki_page:computationalreviewpv-05",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_05_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}