Version history

{
  "scope": "acute slices of mouse auditory cortex, optogenetic activation of contralateral callosal axons; recordings from retrogradely identified CCort vs CCol L5 pyramidal neurons",
  "claim_text": "In mouse auditory cortex, callosal projections recruit L5 pyramidal subnetworks differently by output identity: callosal inputs suppress activity of corticocortical (CCort) L5 pyramidal neurons but facilitate firing of corticocollicular (CCol) L5 pyramidal neurons, with the difference explained by selective callosal activation of fast-spiking PV interneurons.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1523/jneurosci.5049-14.2015",
    "claim": "In mouse auditory cortex, callosal projections recruit L5 pyramidal subnetworks differently by output identity: callosal inputs suppress activity of corticocortical (CCort) L5 pyramidal neurons but facilitate firing of corticocollicular (CCol) L5 pyramidal neurons, with the difference explained by selective callosal activation of fast-spiking PV interneurons.",
    "cite_key": "Rock2015",
    "evidence": "Acute slices of mouse auditory cortex (AC); ChR2 in contralateral AC L5 axons; whole-cell recording from retrogradely identified CCort vs CCol L5 pyramidal neurons; FS-PV identification.",
    "effect_size": "Opposite sign of callosal effect on the two L5 pyramidal classes (suppression vs facilitation).",
    "text_access": "abstract_only",
    "study_system": "acute slices of mouse auditory cortex, optogenetic activation of contralateral callosal axons; recordings from retrogradely identified CCort vs CCol L5 pyramidal neurons",
    "argument_role": "supporting",
    "replication_status": "single_study",
    "claim_source_sentence": "We found that callosal projections suppress the activity of CCort pyramidal neurons, but facilitate firing of CCol pyramidal neurons.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [
      "10.1038/nn1891"
    ],
    "effect_size_source_sentence": null
  },
  "section_id": "section_04",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "effect_size": "Opposite sign of callosal effect on the two L5 pyramidal classes (suppression vs facilitation).",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "source_kind": "review_finding",
  "source_path": "evidence/section_04_evidence_package.json",
  "source_refs": [
    "paper:paper-788d7a788b07"
  ],
  "source_span": "We found that callosal projections suppress the activity of CCort pyramidal neurons, but facilitate firing of CCol pyramidal neurons.",
  "study_system": "acute slices of mouse auditory cortex, optogenetic activation of contralateral callosal axons; recordings from retrogradely identified CCort vs CCol L5 pyramidal neurons",
  "evidence_refs": [
    {
      "ref": "paper:paper-788d7a788b07"
    }
  ],
  "section_title": "4. Translaminar excitatory loops in mouse — L4→L2/3→L5→L6→L4 within the column; asymmetry of forward and backward intracortical projections",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Acute slices of mouse auditory cortex (AC); ChR2 in contralateral AC L5 axons; whole-cell recording from retrogradely identified CCort vs CCol L5 pyramidal neurons; FS-PV identification.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "single_study",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}