In mouse auditory cortex, callosal projections recruit L5 pyramidal subnetworks…

In mouse auditory cortex, callosal projections recruit L5 pyramidal subnetworks differently by output identity: callosal inputs suppress activity of corticocortical (CCort) L5 pyramidal neurons but facilitate firing of corticocollicular (CCol) L5 pyramidal neurons, with the difference explained by selective callosal activation of fast-spiking PV interneurons.

{
  "n": 0,
  "doi": "10.1523/jneurosci.5049-14.2015",
  "claim": "In mouse auditory cortex, callosal projections recruit L5 pyramidal subnetworks differently by output identity: callosal inputs suppress activity of corticocortical (CCort) L5 pyramidal neurons but facilitate firing of corticocollicular (CCol) L5 pyramidal neurons, with the difference explained by selective callosal activation of fast-spiking PV interneurons.",
  "cite_key": "Rock2015",
  "evidence": "Acute slices of mouse auditory cortex (AC); ChR2 in contralateral AC L5 axons; whole-cell recording from retrogradely identified CCort vs CCol L5 pyramidal neurons; FS-PV identification.",
  "effect_size": "Opposite sign of callosal effect on the two L5 pyramidal classes (suppression vs facilitation).",
  "text_access": "abstract_only",
  "study_system": "acute slices of mouse auditory cortex, optogenetic activation of contralateral callosal axons; recordings from retrogradely identified CCort vs CCol L5 pyramidal neurons",
  "argument_role": "supporting",
  "replication_status": "single_study",
  "claim_source_sentence": "We found that callosal projections suppress the activity of CCort pyramidal neurons, but facilitate firing of CCol pyramidal neurons.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [
    "10.1038/nn1891"
  ],
  "effect_size_source_sentence": null
}

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