Version history

{
  "scope": "mouse forelimb primary motor cortex (M1); sCRACM + morphology",
  "claim_text": "In mouse motor cortex (M1), a thin laminar zone at the L3/L5A border houses pyramidal neurons with prototypical L4-like circuit properties — thalamic input, unidirectional ascending excitation to L2/3, and relatively weak long-range inputs — establishing that M1 possesses a functional L4 despite lacking cytoarchitectonic granularity.",
  "raw_fields": {
    "n": 0,
    "doi": "10.7554/elife.05422",
    "claim": "In mouse motor cortex (M1), a thin laminar zone at the L3/L5A border houses pyramidal neurons with prototypical L4-like circuit properties — thalamic input, unidirectional ascending excitation to L2/3, and relatively weak long-range inputs — establishing that M1 possesses a functional L4 despite lacking cytoarchitectonic granularity.",
    "cite_key": "Yamawaki2014",
    "evidence": "Channelrhodopsin-2 input/output mapping, sCRACM, and morphology in mouse forelimb M1.",
    "effect_size": "Identification of M1 L4-equivalent neurons with sensory-cortex-like prototypical microcircuit.",
    "text_access": "abstract_only",
    "study_system": "mouse forelimb primary motor cortex (M1); sCRACM + morphology",
    "argument_role": "supporting",
    "replication_status": "replication_unknown",
    "claim_source_sentence": "Here, we tested the idea that M1, despite lacking a cytoarchitecturally visible L4, nevertheless possesses its equivalent in the form of excitatory neurons with input-output circuits like those of the L4 neurons in sensory areas. Consistent with this idea, we found that neurons located in a thin laminar zone at the L3/5A border in the forelimb area of mouse M1 have multiple L4-like synaptic connections: excitatory input from thalamus, largely unidirectional excitatory outputs to L2/3 pyramidal neurons, and relatively weak long-range corticocortical inputs and outputs.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
  },
  "section_id": "section_04",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "effect_size": "Identification of M1 L4-equivalent neurons with sensory-cortex-like prototypical microcircuit.",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "source_kind": "review_finding",
  "source_path": "evidence/section_04_evidence_package.json",
  "source_refs": [
    "paper:paper-a29242ac688f"
  ],
  "source_span": "Here, we tested the idea that M1, despite lacking a cytoarchitecturally visible L4, nevertheless possesses its equivalent in the form of excitatory neurons with input-output circuits like those of the L4 neurons in sensory areas. Consistent with this idea, we found that neurons located in a thin laminar zone at the L3/5A border in the forelimb area of mouse M1 have multiple L4-like synaptic connections: excitatory i...",
  "study_system": "mouse forelimb primary motor cortex (M1); sCRACM + morphology",
  "evidence_refs": [
    {
      "ref": "paper:paper-a29242ac688f"
    }
  ],
  "section_title": "4. Translaminar excitatory loops in mouse — L4→L2/3→L5→L6→L4 within the column; asymmetry of forward and backward intracortical projections",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Channelrhodopsin-2 input/output mapping, sCRACM, and morphology in mouse forelimb M1.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}