In mouse motor cortex (M1), a thin laminar zone at the L3/L5A border houses pyr…

In mouse motor cortex (M1), a thin laminar zone at the L3/L5A border houses pyramidal neurons with prototypical L4-like circuit properties — thalamic input, unidirectional ascending excitation to L2/3, and relatively weak long-range inputs — establishing that M1 possesses a functional L4 despite lacking cytoarchitectonic granularity.

{
  "n": 0,
  "doi": "10.7554/elife.05422",
  "claim": "In mouse motor cortex (M1), a thin laminar zone at the L3/L5A border houses pyramidal neurons with prototypical L4-like circuit properties — thalamic input, unidirectional ascending excitation to L2/3, and relatively weak long-range inputs — establishing that M1 possesses a functional L4 despite lacking cytoarchitectonic granularity.",
  "cite_key": "Yamawaki2014",
  "evidence": "Channelrhodopsin-2 input/output mapping, sCRACM, and morphology in mouse forelimb M1.",
  "effect_size": "Identification of M1 L4-equivalent neurons with sensory-cortex-like prototypical microcircuit.",
  "text_access": "abstract_only",
  "study_system": "mouse forelimb primary motor cortex (M1); sCRACM + morphology",
  "argument_role": "supporting",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "Here, we tested the idea that M1, despite lacking a cytoarchitecturally visible L4, nevertheless possesses its equivalent in the form of excitatory neurons with input-output circuits like those of the L4 neurons in sensory areas. Consistent with this idea, we found that neurons located in a thin laminar zone at the L3/5A border in the forelimb area of mouse M1 have multiple L4-like synaptic connections: excitatory input from thalamus, largely unidirectional excitatory outputs to L2/3 pyramidal neurons, and relatively weak long-range corticocortical inputs and outputs.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
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Here, we tested the idea that M1, despite lacking a cytoarchitecturally visible L4, nevertheless possesses its equivalent in the form of excitatory neurons with input-output circuits like those of the L4 neurons in sensory areas. Consistent with this idea, we found that neurons located in a thin laminar zone at the L3/5A border in the forelimb area of mouse M1 have multiple L4-like synaptic connections: excitatory i...

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