Version history

{
  "scope": "human dorsal forebrain organoids 8–15 weeks",
  "claim_text": "Dorsal forebrain organoid IN composition shifts over development: LGE-like INs are present at 8 weeks but are gradually replaced by CGE-like INs by 15 weeks, when they constitute the majority of organoid INs. CGE-like INs map to two cardinal subtypes: NR2F2+/PROX1+ (CGE-restricted) and MEIS2+/PAX6+ (CGE+LGE), with predicted fates as cortical INs, olfactory bulb INs, white-matter interstitial neurons, and eccentric striatal projection neurons.",
  "raw_fields": {
    "n": null,
    "doi": "10.1016/j.stem.2023.08.009",
    "claim": "Dorsal forebrain organoid IN composition shifts over development: LGE-like INs are present at 8 weeks but are gradually replaced by CGE-like INs by 15 weeks, when they constitute the majority of organoid INs. CGE-like INs map to two cardinal subtypes: NR2F2+/PROX1+ (CGE-restricted) and MEIS2+/PAX6+ (CGE+LGE), with predicted fates as cortical INs, olfactory bulb INs, white-matter interstitial neurons, and eccentric striatal projection neurons.",
    "title": null,
    "cite_key": "Andrews2023",
    "evidence": "Dorsal forebrain organoid scRNA-seq across 8, 11, 15 weeks; correlation to primary human GE-derived INs.",
    "effect_size": null,
    "figure_data": null,
    "text_access": "fulltext",
    "key_entities": [
      "dorsal organoid",
      "CGE-like",
      "LGE-like",
      "NR2F2",
      "PROX1",
      "MEIS2",
      "PAX6",
      "8 weeks",
      "15 weeks",
      "human",
      "temporal"
    ],
    "study_system": "human dorsal forebrain organoids 8–15 weeks",
    "_source_cluster": "cluster_02_development_lineage",
    "replication_status": "single_study",
    "_source_cluster_index": 129,
    "claim_source_sentence": "We observed that LGE-like INs were present at 8 weeks in organoids but were gradually replaced by CGE-like INs over time. By 15 weeks, the majority of INs in organoids were CGE-like. We found that CGE-like neurons mostly resembled two IN subtypes: NR2F2+/PROX1+ INs found in CGE and MEIS2+/PAX6+ INs found in both CGE and LGE.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
  },
  "section_id": "section_03",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-03-development",
  "source_kind": "review_finding",
  "source_path": "evidence/section_03_evidence_package.json",
  "source_refs": [
    "paper:paper-14ad138608e3"
  ],
  "source_span": "We observed that LGE-like INs were present at 8 weeks in organoids but were gradually replaced by CGE-like INs over time. By 15 weeks, the majority of INs in organoids were CGE-like. We found that CGE-like neurons mostly resembled two IN subtypes: NR2F2+/PROX1+ INs found in CGE and MEIS2+/PAX6+ INs found in both CGE and LGE.",
  "study_system": "human dorsal forebrain organoids 8–15 weeks",
  "evidence_refs": [
    {
      "ref": "paper:paper-14ad138608e3"
    }
  ],
  "section_title": "Developmental Origins and Postnatal Maturation",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Dorsal forebrain organoid scRNA-seq across 8, 11, 15 weeks; correlation to primary human GE-derived INs.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "single_study",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-03-development",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}