Version history

{
  "scope": "mouse S1 barrel cortex; in vivo awake",
  "claim_text": "In barrel cortex in vivo, optogenetic activation of VIP interneurons disinhibits both pyramidal and FS-PV neurons across cortical layers, but a subset of FS neurons (more prevalent in L5/6) are directly inhibited by VIP, indicating layer-dependent VIP→PV vs VIP→SST→PV connectivity.",
  "raw_fields": {
    "n": 89,
    "doi": "10.1016/j.neuron.2019.07.027",
    "claim": "In barrel cortex in vivo, optogenetic activation of VIP interneurons disinhibits both pyramidal and FS-PV neurons across cortical layers, but a subset of FS neurons (more prevalent in L5/6) are directly inhibited by VIP, indicating layer-dependent VIP→PV vs VIP→SST→PV connectivity.",
    "title": null,
    "cite_key": "Yu2019",
    "evidence": "In vivo silicon-probe extracellular recordings + ChR2 photo-tagging of VIP, SST, PV in awake barrel cortex.",
    "effect_size": "SST n=89 (14 whole-cell), VIP n=9; layer-dependent disinhibition.",
    "text_access": "fulltext",
    "study_system": "mouse S1 barrel cortex; in vivo awake",
    "_source_cluster": "cluster_05_synaptic_connectivity",
    "replication_status": "replicated",
    "_source_cluster_index": 7,
    "claim_source_sentence": "The majority of FS neurons in all layers were disinhibited by VIP neuron activation, but direct inhibition from VIP to FS neurons also existed and was more prevalent for L5/6 FS neurons ( ; ).",
    "replication_evidence_dois": [
      "10.1038/nn.3446"
    ],
    "effect_size_source_sentence": "To detect SST (n = 89, including 14 whole-cell recordings) or VIP (n = 9) neurons, we selectively expressed ChR2 in either type by crossing SST-IRES-Cre or VIP-IRES-Cre mice ( ) with a ChR2 reporter line, Ai32 ( ), and exploited light-driven responses to identify these neurons ( \n- A subset of SST and VIP neurons were labeled to verify their recording locations ( and )."
  },
  "section_id": "section_06",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_06_evidence_package.json",
  "effect_size": "SST n=89 (14 whole-cell), VIP n=9; layer-dependent disinhibition.",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-06-synaptic-properties",
  "source_kind": "review_finding",
  "source_path": "evidence/section_06_evidence_package.json",
  "source_refs": [
    "paper:e5dc2921-2ba0-4d4f-a34c-67e2b13a356d"
  ],
  "source_span": "The majority of FS neurons in all layers were disinhibited by VIP neuron activation, but direct inhibition from VIP to FS neurons also existed and was more prevalent for L5/6 FS neurons ( ; ).",
  "study_system": "mouse S1 barrel cortex; in vivo awake",
  "evidence_refs": [
    {
      "ref": "paper:e5dc2921-2ba0-4d4f-a34c-67e2b13a356d"
    }
  ],
  "section_title": "Synaptic Properties and Connectivity",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "In vivo silicon-probe extracellular recordings + ChR2 photo-tagging of VIP, SST, PV in awake barrel cortex.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replicated",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-06-synaptic-properties",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_06_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}