Details
- scope
- mouse S1 barrel cortex; in vivo awake
- section_id
- section_06
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_06_evidence_package.json
- effect_size
- SST n=89 (14 whole-cell), VIP n=9; layer-dependent disinhibition.
- review_repo
- ComputationalReviewVIP
- section_ref
- wiki_page:computationalreviewvip-06-synaptic-properties
- source_kind
- review_finding
- source_path
- evidence/section_06_evidence_package.json
- source_span
- The majority of FS neurons in all layers were disinhibited by VIP neuron activation, but direct inhibition from VIP to FS neurons also existed and was more prevalent for L5/6 FS neurons ( ; ).
- study_system
- mouse S1 barrel cortex; in vivo awake
- section_title
- Synaptic Properties and Connectivity
- evidence_summary
- In vivo silicon-probe extracellular recordings + ChR2 photo-tagging of VIP, SST, PV in awake barrel cortex.
- review_bundle_ref
- analysis_bundle:ab-2ce40c33e827
- replication_status
- replicated
- review_package_ref
- analysis_bundle:ab-2ce40c33e827
- source_artifact_ref
- wiki_page:computationalreviewvip-06-synaptic-properties
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_06_evidence_package.json
- commit_sha
- 95e761177f7d2ec565983d3307c14ec238f9677c
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP
Raw fields (5)
- claim_text
In barrel cortex in vivo, optogenetic activation of VIP interneurons disinhibits both pyramidal and FS-PV neurons across cortical layers, but a subset of FS neurons (more prevalent in L5/6) are directly inhibited by VIP, indicating layer-dependent VIP→PV vs VIP→SST→PV connectivity.
- raw_fields
{ "n": 89, "doi": "10.1016/j.neuron.2019.07.027", "claim": "In barrel cortex in vivo, optogenetic activation of VIP interneurons disinhibits both pyramidal and FS-PV neurons across cortical layers, but a subset of FS neurons (more prevalent in L5/6) are directly inhibited by VIP, indicating layer-dependent VIP→PV vs VIP→SST→PV connectivity.", "title": null, "cite_key": "Yu2019", "evidence": "In vivo silicon-probe extracellular recordings + ChR2 photo-tagging of VIP, SST, PV in awake barrel cortex.", "effect_size": "SST n=89 (14 whole-cell), VIP n=9; layer-dependent disinhibition.", "text_access": "fulltext", "study_system": "mouse S1 barrel cortex; in vivo awake", "_source_cluster": "cluster_05_synaptic_connectivity", "replication_status": "replicated", "_source_cluster_index": 7, "claim_source_sentence": "The majority of FS neurons in all layers were disinhibited by VIP neuron activation, but direct inhibition from VIP to FS neurons also existed and was more prevalent for L5/6 FS neurons ( ; ).", "replication_evidence_dois": [ "10.1038/nn.3446" ], "effect_size_source_sentence": "To detect SST (n = 89, including 14 whole-cell recordings) or VIP (n = 9) neurons, we selectively expressed ChR2 in either type by crossing SST-IRES-Cre or VIP-IRES-Cre mice ( ) with a ChR2 reporter line, Ai32 ( ), and exploited light-driven responses to identify these neurons ( \n- A subset of SST and VIP neurons were labeled to verify their recording locations ( and )." }- source_refs
[ "paper:e5dc2921-2ba0-4d4f-a34c-67e2b13a356d" ]
- evidence_refs
[ { "ref": "paper:e5dc2921-2ba0-4d4f-a34c-67e2b13a356d" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP" }