- raw_fields
{
"n": 0,
"doi": "10.1016/j.neuron.2021.07.030",
"claim": "Increasing the stability of newly formed dendritic spines (via PirB loss or acute PirB inhibition in adult M1) enhances motor learning in mice; the survival of new spines correlates with performance.",
"cite_key": "Albarran2021",
"evidence": "PirB-knockout mice had increased spine formation and density and learned a skilled reaching task faster than wild-type; acute PirB inhibition in adult M1 increased learning-induced spine survival and enhanced motor learning. Single-spine uncaging implicated PirB in NMDAR-dependent spine shrinkage.",
"effect_size": null,
"text_access": "abstract_only",
"study_system": "Mouse motor cortex (M1) pyramidal neurons during skilled forelimb reaching",
"argument_role": "supporting",
"replication_status": "replication_unknown",
"claim_source_sentence": "The degree of survival of newly formed spines correlates with performance, suggesting that increased spine stability is advantageous for learning.",
"source_provenance_status": "non_substring_match",
"replication_evidence_dois": [],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-5788e3e6aa69"
]
- evidence_refs
[
{
"ref": "paper:paper-5788e3e6aa69"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}- evidence_summary
PirB-knockout mice had increased spine formation and density and learned a skilled reaching task faster than wild-type; acute PirB inhibition in adult M1 increased learning-induced spine survival and enhanced motor learning. Single-spine uncaging implicated PirB in NMDAR-dependent spine shrinkage.