Version history

{
  "scope": "rodent mPFC; ChAT-Cre/VIP-Cre intersectional",
  "claim_text": "Cortical ChAT-VIP interneurons (a small subset of the VIP class co-expressing choline acetyltransferase and the vesicular ACh transporter SLC18A3) directly *excite* neighboring L1–L3 interneurons and L2/3 + L6 pyramidal cells through fast cholinergic synaptic transmission, in stark contrast to regular VIP cells which disinhibit pyramidal neurons by suppressing SST cells — making ChAT-VIP a functionally distinct VIP sub-class with its own intrinsic-physiology + behavioral role.",
  "raw_fields": {
    "n": null,
    "doi": "10.1038/s41467-019-13244-9",
    "claim": "Cortical ChAT-VIP interneurons (a small subset of the VIP class co-expressing choline acetyltransferase and the vesicular ACh transporter SLC18A3) directly *excite* neighboring L1–L3 interneurons and L2/3 + L6 pyramidal cells through fast cholinergic synaptic transmission, in stark contrast to regular VIP cells which disinhibit pyramidal neurons by suppressing SST cells — making ChAT-VIP a functionally distinct VIP sub-class with its own intrinsic-physiology + behavioral role.",
    "title": null,
    "cite_key": "Obermayer2019",
    "evidence": "in vitro paired patch-clamp + optogenetics in mouse mPFC; behavioral attention assays",
    "effect_size": "qualitative — ChAT-VIP excite (don't disinhibit); fast cholinergic + GABA co-transmission in 10–20% of postsynaptic INs",
    "text_access": "fulltext",
    "study_system": "rodent mPFC; ChAT-Cre/VIP-Cre intersectional",
    "_source_cluster": "cluster_04_intrinsic_electrophysiology",
    "replication_status": "replication_unknown",
    "_source_cluster_index": 60,
    "claim_source_sentence": "ChAT-VIP neurons directly excite neighbouring neurons in several layers through fast synaptic transmission of acetylcholine (ACh) in rodent medial prefrontal cortex (mPFC).",
    "replication_evidence_dois": [
      "10.1038/nn.4216"
    ],
    "effect_size_source_sentence": "In contrast to regular VIP interneurons, ChAT-VIP neurons did not disinhibit pyramidal neurons."
  },
  "section_id": "section_05",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json",
  "effect_size": "qualitative — ChAT-VIP excite (don't disinhibit); fast cholinergic + GABA co-transmission in 10–20% of postsynaptic INs",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-05-electrophysiology",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-d66bdd18df1c"
  ],
  "source_span": "ChAT-VIP neurons directly excite neighbouring neurons in several layers through fast synaptic transmission of acetylcholine (ACh) in rodent medial prefrontal cortex (mPFC).",
  "study_system": "rodent mPFC; ChAT-Cre/VIP-Cre intersectional",
  "evidence_refs": [
    {
      "ref": "paper:paper-d66bdd18df1c"
    }
  ],
  "section_title": "Intrinsic Electrophysiology",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "in vitro paired patch-clamp + optogenetics in mouse mPFC; behavioral attention assays",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-05-electrophysiology",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}