- raw_fields
{
"n": 0,
"doi": "10.3390/ijms25105549",
"claim": "PV+ interneuron dysfunction disrupts E/I balance and is linked to epilepsy, Alzheimer's disease, and cognitive decline; optogenetic/chemogenetic manipulation can control seizures",
"evidence": "Review of optogenetic and chemogenetic studies targeting PV interneurons",
"effect_size": null,
"text_access": "fulltext",
"study_system": "review of animal models with PV interneuron dysfunction",
"replication_status": "replication_unknown",
"claim_source_sentence": "PV+ interneurons are also key players in generating gamma oscillations, which are synchronized neural oscillations associated with various cognitive functions. PV+ interneuron are particularly vulnerable to aging and their degeneration has been associated with cognitive decline and memory impairment in dementia and Alzheimer's disease (AD).",
"replication_evidence_dois": [],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-996f97370d49"
]
- source_span
PV+ interneurons are also key players in generating gamma oscillations, which are synchronized neural oscillations associated with various cognitive functions. PV+ interneuron are particularly vulnerable to aging and their degeneration has been associated with cognitive decline and memory impairment in dementia and Alzheimer's disease (AD).
- evidence_refs
[
{
"ref": "paper:paper-996f97370d49"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}