Version history

{
  "scope": "review of animal models with PV interneuron dysfunction",
  "claim_text": "PV+ interneuron dysfunction disrupts E/I balance and is linked to epilepsy, Alzheimer's disease, and cognitive decline; optogenetic/chemogenetic manipulation can control seizures",
  "raw_fields": {
    "n": 0,
    "doi": "10.3390/ijms25105549",
    "claim": "PV+ interneuron dysfunction disrupts E/I balance and is linked to epilepsy, Alzheimer's disease, and cognitive decline; optogenetic/chemogenetic manipulation can control seizures",
    "evidence": "Review of optogenetic and chemogenetic studies targeting PV interneurons",
    "effect_size": null,
    "text_access": "fulltext",
    "study_system": "review of animal models with PV interneuron dysfunction",
    "replication_status": "replication_unknown",
    "claim_source_sentence": "PV+ interneurons are also key players in generating gamma oscillations, which are synchronized neural oscillations associated with various cognitive functions. PV+ interneuron are particularly vulnerable to aging and their degeneration has been associated with cognitive decline and memory impairment in dementia and Alzheimer's disease (AD).",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
  },
  "section_id": "section_12_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_12_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-12",
  "source_kind": "review_finding",
  "source_path": "evidence/section_12_evidence_package.json",
  "source_refs": [
    "paper:paper-996f97370d49"
  ],
  "source_span": "PV+ interneurons are also key players in generating gamma oscillations, which are synchronized neural oscillations associated with various cognitive functions. PV+ interneuron are particularly vulnerable to aging and their degeneration has been associated with cognitive decline and memory impairment in dementia and Alzheimer's disease (AD).",
  "study_system": "review of animal models with PV interneuron dysfunction",
  "evidence_refs": [
    {
      "ref": "paper:paper-996f97370d49"
    }
  ],
  "section_title": "Computational Models of PV Circuit Function",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "evidence_summary": "Review of optogenetic and chemogenetic studies targeting PV interneurons",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-e6261c8263e7",
  "source_artifact_ref": "wiki_page:computationalreviewpv-12",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_12_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}