A single dose of psilocybin in mice produces ~10% increases in apical dendritic…

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scope: Mouse medial frontal cortex L5 pyramidal apical dendrites (in vivo two-photon)
claim_text: A single dose of psilocybin in mice produces ~10% increases in apical dendritic spine size and density on layer 5 pyramidal neurons in medial frontal cortex within 24 h, persisting at least 1 month.
section_id: section_12
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_12_evidence_package.json
effect_size: ~10% increase in spine size and density at 24 h; persistent at 1 month
review_repo: ComputationalReviewRecurrence
section_ref: wiki_page:computationalreviewrecurrence-12-plasticity
source_kind: review_finding
source_path: evidence/section_12_evidence_package.json
source_span: We found that a single dose of psilocybin led to ∼10% increases in spine size and density, driven by an elevated spine formation rate.
study_system: Mouse medial frontal cortex L5 pyramidal apical dendrites (in vivo two-photon)
section_title: 12. Plasticity at E→E synapses in mouse — Hebbian, STDP, behavioural-time-scale plasticity; how plasticity shapes the recurrent matrix during learning
evidence_summary: Chronic two-photon imaging of L5 pyramidal apical spines in mouse medial frontal cortex showed ~10% increase in size and density within 24 h after a single psilocybin dose, persistent at 1 month, with elevated formation rate.
review_bundle_ref: analysis_bundle:ab-d9c479db9be9
replication_status: replication_unknown
review_package_ref: analysis_bundle:ab-d9c479db9be9
source_artifact_ref: wiki_page:computationalreviewrecurrence-12-plasticity
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_12_evidence_package.json
commit_sha: 79ce062d54a924ce05953ec90aa9d26044d2b48f
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence

Raw fields (4)

raw_fields

{
  "n": 0,
  "doi": "10.1016/j.neuron.2021.06.008",
  "claim": "A single dose of psilocybin in mice produces ~10% increases in apical dendritic spine size and density on layer 5 pyramidal neurons in medial frontal cortex within 24 h, persisting at least 1 month.",
  "cite_key": "Shao2021",
  "evidence": "Chronic two-photon imaging of L5 pyramidal apical spines in mouse medial frontal cortex showed ~10% increase in size and density within 24 h after a single psilocybin dose, persistent at 1 month, with elevated formation rate.",
  "effect_size": "~10% increase in spine size and density at 24 h; persistent at 1 month",
  "text_access": "abstract_only",
  "study_system": "Mouse medial frontal cortex L5 pyramidal apical dendrites (in vivo two-photon)",
  "argument_role": "supporting",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "We found that a single dose of psilocybin led to ∼10% increases in spine size and density, driven by an elevated spine formation rate.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "We found that a single dose of psilocybin led to ∼10% increases in spine size and density, driven by an elevated spine formation rate."
}

source_refs

[
  "paper:paper-95b8dca171dd"
]

evidence_refs

[
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    "ref": "paper:paper-95b8dca171dd"
  }
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source_policy

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A single dose of psilocybin in mice produces ~10% increases in apical dendritic…

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