Details
- scope
- europepmc_q8
- claim_text
- Biophysical K<sub>v</sub>3 channel alterations dampen excitability of cortical PV interneurons and contribute to network hyperexcitability in early Alzheimer's
- section_id
- section_12_evidence_package
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_12_evidence_package.json
- review_repo
- ComputationalReviewPV
- section_ref
- wiki_page:computationalreviewpv-12
- source_kind
- review_finding
- source_path
- evidence/section_12_evidence_package.json
- source_span
- We found that biophysical modulation of K<sub>v</sub>3 channels, but not changes in their mRNA or protein expression, were responsible for dampened excitability in young 5xFAD mice.
- study_system
- europepmc_q8
- section_title
- Computational Models of PV Circuit Function
- evidence_summary
- In Alzheimer's disease (AD), a multitude of genetic risk factors and early biomarkers are known. Nevertheless, the causal factors responsible for initiating cognitive decline in AD remain controversia
- review_bundle_ref
- analysis_bundle:ab-e6261c8263e7
- replication_status
- replication_unknown
- review_package_ref
- analysis_bundle:ab-e6261c8263e7
- source_artifact_ref
- wiki_page:computationalreviewpv-12
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_12_evidence_package.json
- commit_sha
- df9fc7e8d455b084152c9d713558dae0013cef21
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV
Raw fields (4)
- raw_fields
{ "n": 0, "doi": "10.7554/elife.75316", "claim": "Biophysical K<sub>v</sub>3 channel alterations dampen excitability of cortical PV interneurons and contribute to network hyperexcitability in early Alzheimer's", "evidence": "In Alzheimer's disease (AD), a multitude of genetic risk factors and early biomarkers are known. Nevertheless, the causal factors responsible for initiating cognitive decline in AD remain controversia", "effect_size": null, "text_access": "abstract_only", "study_system": "europepmc_q8", "replication_status": "replication_unknown", "claim_source_sentence": "We found that biophysical modulation of K<sub>v</sub>3 channels, but not changes in their mRNA or protein expression, were responsible for dampened excitability in young 5xFAD mice.", "replication_evidence_dois": [], "effect_size_source_sentence": null }- source_refs
[ "paper:paper-9faa92469da0" ]
- evidence_refs
[ { "ref": "paper:paper-9faa92469da0" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV" }