Version history

{
  "scope": "europepmc_q8",
  "claim_text": "Biophysical K<sub>v</sub>3 channel alterations dampen excitability of cortical PV interneurons and contribute to network hyperexcitability in early Alzheimer's",
  "raw_fields": {
    "n": 0,
    "doi": "10.7554/elife.75316",
    "claim": "Biophysical K<sub>v</sub>3 channel alterations dampen excitability of cortical PV interneurons and contribute to network hyperexcitability in early Alzheimer's",
    "evidence": "In Alzheimer's disease (AD), a multitude of genetic risk factors and early biomarkers are known. Nevertheless, the causal factors responsible for initiating cognitive decline in AD remain controversia",
    "effect_size": null,
    "text_access": "abstract_only",
    "study_system": "europepmc_q8",
    "replication_status": "replication_unknown",
    "claim_source_sentence": "We found that biophysical modulation of K<sub>v</sub>3 channels, but not changes in their mRNA or protein expression, were responsible for dampened excitability in young 5xFAD mice.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
  },
  "section_id": "section_12_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_12_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-12",
  "source_kind": "review_finding",
  "source_path": "evidence/section_12_evidence_package.json",
  "source_refs": [
    "paper:paper-9faa92469da0"
  ],
  "source_span": "We found that biophysical modulation of K<sub>v</sub>3 channels, but not changes in their mRNA or protein expression, were responsible for dampened excitability in young 5xFAD mice.",
  "study_system": "europepmc_q8",
  "evidence_refs": [
    {
      "ref": "paper:paper-9faa92469da0"
    }
  ],
  "section_title": "Computational Models of PV Circuit Function",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "evidence_summary": "In Alzheimer's disease (AD), a multitude of genetic risk factors and early biomarkers are known. Nevertheless, the causal factors responsible for initiating cognitive decline in AD remain controversia",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-e6261c8263e7",
  "source_artifact_ref": "wiki_page:computationalreviewpv-12",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_12_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}