GABAergic synaptic inputs produce non-monotonic effects on neuronal firing: sma…

Details

scope: single neuron models (multiple types) and striatal microcircuit model with FS interneurons
claim_text: GABAergic synaptic inputs produce non-monotonic effects on neuronal firing: small GABA conductances are excitatory while large conductances are inhibitory for intermediate GABA reversal potentials
section_id: section_12_evidence_package
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_12_evidence_package.json
review_repo: ComputationalReviewPV
section_ref: wiki_page:computationalreviewpv-12
source_kind: review_finding
source_path: evidence/section_12_evidence_package.json
source_span: In the non-monotonic regime, small GABA conductances have an excitatory effect while large GABA conductances show an inhibitory effect.
study_system: single neuron models (multiple types) and striatal microcircuit model with FS interneurons
section_title: Computational Models of PV Circuit Function
evidence_summary: Analytical calculations and numerical simulations across multiple single-neuron models; striatal microcircuit model
review_bundle_ref: analysis_bundle:ab-e6261c8263e7
replication_status: replication_unknown
review_package_ref: analysis_bundle:ab-e6261c8263e7
source_artifact_ref: wiki_page:computationalreviewpv-12
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_12_evidence_package.json
commit_sha: df9fc7e8d455b084152c9d713558dae0013cef21
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV

Raw fields (4)

raw_fields

{
  "n": 0,
  "doi": "10.1371/journal.pcbi.1010226",
  "claim": "GABAergic synaptic inputs produce non-monotonic effects on neuronal firing: small GABA conductances are excitatory while large conductances are inhibitory for intermediate GABA reversal potentials",
  "evidence": "Analytical calculations and numerical simulations across multiple single-neuron models; striatal microcircuit model",
  "effect_size": null,
  "text_access": "fulltext",
  "study_system": "single neuron models (multiple types) and striatal microcircuit model with FS interneurons",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "In the non-monotonic regime, small GABA conductances have an excitatory effect while large GABA conductances show an inhibitory effect.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

source_refs

[
  "paper:paper-c9afbde00fc1"
]

evidence_refs

[
  {
    "ref": "paper:paper-c9afbde00fc1"
  }
]

source_policy

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}

GABAergic synaptic inputs produce non-monotonic effects on neuronal firing: sma…

Details

Replication

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