Version history

{
  "scope": "mouse vibrissal M1 (vM1) slices; ChR2-assisted circuit mapping",
  "claim_text": "In mouse vibrissal primary motor cortex, channelrhodopsin-2-assisted circuit mapping shows that long-range cortical and thalamic inputs to pyramidal neurons each adopt a distinct laminar profile that together tile all cortical layers.",
  "raw_fields": {
    "n": "mouse vM1, slice optogenetics + whole-cell, n not stated in abstract",
    "doi": "10.1523/jneurosci.4338-12.2013",
    "claim": "In mouse vibrissal primary motor cortex, channelrhodopsin-2-assisted circuit mapping shows that long-range cortical and thalamic inputs to pyramidal neurons each adopt a distinct laminar profile that together tile all cortical layers.",
    "cite_key": "Hooks2013",
    "evidence": "Optogenetic stimulation of axons from orbital cortex, secondary motor cortex, and motor- and sensory-related thalamic regions produced layer-specific excitatory inputs (OC→L6; M2→L5B; VA/VL→L2/3-L5B avoiding L6; POm and S1→L2/3 and L5A).",
    "effect_size": "qualitative laminar segregation (no single number reported in abstract)",
    "text_access": "abstract_only",
    "study_system": "mouse vibrissal M1 (vM1) slices; ChR2-assisted circuit mapping",
    "argument_role": "supporting",
    "replication_status": "consistent with subsequent vM1 input maps (Yamawaki 2014, 2015)",
    "claim_source_sentence": "Each projection innervated vM1 pyramidal neurons with a unique laminar profile. Collectively, the profiles for different sources of input partially overlapped and spanned all cortical layers.",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [
      "10.7554/eLife.05422"
    ],
    "effect_size_source_sentence": "Specifically, orbital cortex (OC) inputs primarily targeted neurons in L6. Secondary motor cortex (M2) inputs excited neurons mainly in L5B, including pyramidal tract neurons."
  },
  "section_id": "section_04",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "effect_size": "qualitative laminar segregation (no single number reported in abstract)",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "source_kind": "review_finding",
  "source_path": "evidence/section_04_evidence_package.json",
  "source_refs": [
    "paper:fc06108f-75bb-4dd7-9d5e-3b006f8c4156"
  ],
  "source_span": "Each projection innervated vM1 pyramidal neurons with a unique laminar profile. Collectively, the profiles for different sources of input partially overlapped and spanned all cortical layers.",
  "study_system": "mouse vibrissal M1 (vM1) slices; ChR2-assisted circuit mapping",
  "evidence_refs": [
    {
      "ref": "paper:fc06108f-75bb-4dd7-9d5e-3b006f8c4156"
    }
  ],
  "section_title": "4. Translaminar excitatory loops in mouse — L4→L2/3→L5→L6→L4 within the column; asymmetry of forward and backward intracortical projections",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Optogenetic stimulation of axons from orbital cortex, secondary motor cortex, and motor- and sensory-related thalamic regions produced layer-specific excitatory inputs (OC→L6; M2→L5B; VA/VL→L2/3-L5B avoiding L6; POm and S1→L2/3 and L5A).",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "consistent with subsequent vM1 input maps (Yamawaki 2014, 2015)",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}