In mouse vibrissal primary motor cortex, channelrhodopsin-2-assisted circuit ma…

{
  "n": "mouse vM1, slice optogenetics + whole-cell, n not stated in abstract",
  "doi": "10.1523/jneurosci.4338-12.2013",
  "claim": "In mouse vibrissal primary motor cortex, channelrhodopsin-2-assisted circuit mapping shows that long-range cortical and thalamic inputs to pyramidal neurons each adopt a distinct laminar profile that together tile all cortical layers.",
  "cite_key": "Hooks2013",
  "evidence": "Optogenetic stimulation of axons from orbital cortex, secondary motor cortex, and motor- and sensory-related thalamic regions produced layer-specific excitatory inputs (OC→L6; M2→L5B; VA/VL→L2/3-L5B avoiding L6; POm and S1→L2/3 and L5A).",
  "effect_size": "qualitative laminar segregation (no single number reported in abstract)",
  "text_access": "abstract_only",
  "study_system": "mouse vibrissal M1 (vM1) slices; ChR2-assisted circuit mapping",
  "argument_role": "supporting",
  "replication_status": "consistent with subsequent vM1 input maps (Yamawaki 2014, 2015)",
  "claim_source_sentence": "Each projection innervated vM1 pyramidal neurons with a unique laminar profile. Collectively, the profiles for different sources of input partially overlapped and spanned all cortical layers.",
  "source_provenance_status": "ok",
  "replication_evidence_dois": [
    "10.7554/eLife.05422"
  ],
  "effect_size_source_sentence": "Specifically, orbital cortex (OC) inputs primarily targeted neurons in L6. Secondary motor cortex (M2) inputs excited neurons mainly in L5B, including pyramidal tract neurons."
}

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]

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]

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