Version history

{
  "scope": "mouse hippocampus, conditional GluA KO in CGE-derived interneurons",
  "claim_text": "Conditional removal of all AMPAR subunits (GluA1/2/3 KO) in CGE-derived interneurons increases their early postnatal numbers but causes later apoptosis to converge with wild-type, reduces feedforward and feedback inhibition onto pyramidal neurons, and produces behavioural abnormalities — establishing that AMPAR-mediated glutamatergic drive is required for postnatal maturation of CGE-derived interneurons.",
  "raw_fields": {
    "n": null,
    "doi": "10.1038/s41598-019-41920-9",
    "claim": "Conditional removal of all AMPAR subunits (GluA1/2/3 KO) in CGE-derived interneurons increases their early postnatal numbers but causes later apoptosis to converge with wild-type, reduces feedforward and feedback inhibition onto pyramidal neurons, and produces behavioural abnormalities — establishing that AMPAR-mediated glutamatergic drive is required for postnatal maturation of CGE-derived interneurons.",
    "title": null,
    "cite_key": "Akgul2019",
    "evidence": "Body, Results/Discussion: conditional knockout of GluA1&2&3 in CGE-derived interneurons; sEPSC recordings, anatomical density, behaviour.",
    "effect_size": "GluA1-3 KO almost completely eliminates sEPSCs in CGE interneurons; reduces feedforward and feedback inhibition onto pyramidal neurons",
    "text_access": "fulltext",
    "study_system": "mouse hippocampus, conditional GluA KO in CGE-derived interneurons",
    "_source_cluster": "cluster_02_development_lineage",
    "replication_status": "single-study",
    "_source_cluster_index": 4,
    "claim_source_sentence": "Moreover, in GluA1-3 KOs, the number of interneurons invading the hippocampus increased in the early postnatal period but converged with WT numbers later due to increased apoptosis.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Removal of GluA1&2&3 subunits (GluA1-3 KO) in CGE-derived interneurons, almost completely eliminated sEPSCs without further reducing synapse density, but increased dendritic branching."
  },
  "section_id": "section_03",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "effect_size": "GluA1-3 KO almost completely eliminates sEPSCs in CGE interneurons; reduces feedforward and feedback inhibition onto pyramidal neurons",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-03-development",
  "source_kind": "review_finding",
  "source_path": "evidence/section_03_evidence_package.json",
  "source_refs": [
    "paper:paper-79bc1ea73c7e"
  ],
  "source_span": "Moreover, in GluA1-3 KOs, the number of interneurons invading the hippocampus increased in the early postnatal period but converged with WT numbers later due to increased apoptosis.",
  "study_system": "mouse hippocampus, conditional GluA KO in CGE-derived interneurons",
  "evidence_refs": [
    {
      "ref": "paper:paper-79bc1ea73c7e"
    }
  ],
  "section_title": "Developmental Origins and Postnatal Maturation",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Body, Results/Discussion: conditional knockout of GluA1&2&3 in CGE-derived interneurons; sEPSC recordings, anatomical density, behaviour.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "single-study",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-03-development",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}