Conditional removal of all AMPAR subunits (GluA1/2/3 KO) in CGE-derived interne…

Conditional removal of all AMPAR subunits (GluA1/2/3 KO) in CGE-derived interneurons increases their early postnatal numbers but causes later apoptosis to converge with wild-type, reduces feedforward and feedback inhibition onto pyramidal neurons, and produces behavioural abnormalities — establishing that AMPAR-mediated glutamatergic drive is required for postnatal maturation of CGE-derived interneurons.

{
  "n": null,
  "doi": "10.1038/s41598-019-41920-9",
  "claim": "Conditional removal of all AMPAR subunits (GluA1/2/3 KO) in CGE-derived interneurons increases their early postnatal numbers but causes later apoptosis to converge with wild-type, reduces feedforward and feedback inhibition onto pyramidal neurons, and produces behavioural abnormalities — establishing that AMPAR-mediated glutamatergic drive is required for postnatal maturation of CGE-derived interneurons.",
  "title": null,
  "cite_key": "Akgul2019",
  "evidence": "Body, Results/Discussion: conditional knockout of GluA1&2&3 in CGE-derived interneurons; sEPSC recordings, anatomical density, behaviour.",
  "effect_size": "GluA1-3 KO almost completely eliminates sEPSCs in CGE interneurons; reduces feedforward and feedback inhibition onto pyramidal neurons",
  "text_access": "fulltext",
  "study_system": "mouse hippocampus, conditional GluA KO in CGE-derived interneurons",
  "_source_cluster": "cluster_02_development_lineage",
  "replication_status": "single-study",
  "_source_cluster_index": 4,
  "claim_source_sentence": "Moreover, in GluA1-3 KOs, the number of interneurons invading the hippocampus increased in the early postnatal period but converged with WT numbers later due to increased apoptosis.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "Removal of GluA1&2&3 subunits (GluA1-3 KO) in CGE-derived interneurons, almost completely eliminated sEPSCs without further reducing synapse density, but increased dendritic branching."
}

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