In mouse forelimb motor cortex, intracortical excitatory connectivity is asymme…

In mouse forelimb motor cortex, intracortical excitatory connectivity is asymmetric across layer-6 corticothalamic (CT), intratelencephalic (IT), and layer-5 pyramidal-tract (PT) projection classes: CT↔IT connections are limited to L6 IT and CT↔PT connectivity is strikingly weak.

{
  "n": null,
  "doi": "10.1523/jneurosci.4023-14.2015",
  "claim": "In mouse forelimb motor cortex, intracortical excitatory connectivity is asymmetric across layer-6 corticothalamic (CT), intratelencephalic (IT), and layer-5 pyramidal-tract (PT) projection classes: CT↔IT connections are limited to L6 IT and CT↔PT connectivity is strikingly weak.",
  "cite_key": "Yamawaki2015",
  "evidence": "Channelrhodopsin-2-assisted circuit mapping plus paired recordings in M1 of mouse, dissecting CT/IT/PT connectivity and CT–thalamus reciprocal connections.",
  "effect_size": "Strong CT↔CT and CT↔IT (L6) connectivity; near-absent CT↔PT excitation; M1-CT and ventrolateral thalamus largely unconnected in either direction.",
  "text_access": "abstract_only",
  "study_system": "Mouse forelimb motor cortex (M1); ex vivo slice physiology",
  "argument_role": "supporting",
  "replication_status": "single-study",
  "claim_source_sentence": "Stimulating and recording from CT, intratelencephalic (IT), and pyramidal tract (PT) projection neurons, we found strong CT↔ CT and CT↔ IT connections; however, CT→IT connections were limited to IT neurons in layer 6, not 5B.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "There was strikingly little CT↔ PT excitatory connectivity."
}

[
  "paper:paper-77ff3f69a352"
]

Stimulating and recording from CT, intratelencephalic (IT), and pyramidal tract (PT) projection neurons, we found strong CT↔ CT and CT↔ IT connections; however, CT→IT connections were limited to IT neurons in layer 6, not 5B.

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