Version history

{
  "scope": "rate/spiking microcircuit model + EEG comparison",
  "claim_text": "Computational modeling of a PV–SST–VIP cortical circuit reproduces ketamine-induced gamma changes, attributing increased gamma to PV hypofunction modulated by VIP-driven disinhibition.",
  "raw_fields": {
    "n": null,
    "id": "cluster_11_finding_10",
    "doi": "10.1371/journal.pcbi.1013118",
    "pmid": "40489551",
    "year": "2025",
    "claim": "Computational modeling of a PV–SST–VIP cortical circuit reproduces ketamine-induced gamma changes, attributing increased gamma to PV hypofunction modulated by VIP-driven disinhibition.",
    "pmcid": "PMC12204622",
    "title": "Computational modeling of ketamine-induced changes in gamma-band oscillations: The contribution of parvalbumin and somatostatin interneurons.",
    "authors": "Rademacher J, Grent-'t-Jong T, Rivolta D, Sauer A, Scheller B, Gonzalez-Burgos G, Metzner C, Uhlhaas PJ.",
    "journal": "PLoS computational biology",
    "cite_key": "Rademacher2025",
    "evidence": "NMDA hypofunction parameter sweeps mapped onto interneuron synapses; gamma power increases when PV-NMDA reduced and VIP recruitment shifted.",
    "effect_size": null,
    "text_access": "fulltext",
    "study_system": "rate/spiking microcircuit model + EEG comparison",
    "_source_cluster": "cluster_11_computational_models",
    "replication_status": "replication_unknown",
    "_source_cluster_index": 9,
    "claim_source_sentence": "Finally, vasoactive intestinal peptide-expressing (VIP+) interneurons, which mainly target other GABAergic interneurons, including the PV+ and SST+ subclasses [ 25 ], may promote the disinhibition of pyramidal cells thus modulating oscillatory activity.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
  },
  "section_id": "section_12",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_12_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-12-computational-models",
  "source_kind": "review_finding",
  "source_path": "evidence/section_12_evidence_package.json",
  "source_refs": [
    "paper:paper-1f9e2fd192d2"
  ],
  "source_span": "Finally, vasoactive intestinal peptide-expressing (VIP+) interneurons, which mainly target other GABAergic interneurons, including the PV+ and SST+ subclasses [ 25 ], may promote the disinhibition of pyramidal cells thus modulating oscillatory activity.",
  "study_system": "rate/spiking microcircuit model + EEG comparison",
  "evidence_refs": [
    {
      "ref": "paper:paper-1f9e2fd192d2"
    }
  ],
  "section_title": "Computational Models of VIP Circuit Function",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "NMDA hypofunction parameter sweeps mapped onto interneuron synapses; gamma power increases when PV-NMDA reduced and VIP recruitment shifted.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-12-computational-models",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_12_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}