Details
- scope
- rate/spiking microcircuit model + EEG comparison
- claim_text
- Computational modeling of a PV–SST–VIP cortical circuit reproduces ketamine-induced gamma changes, attributing increased gamma to PV hypofunction modulated by VIP-driven disinhibition.
- section_id
- section_12
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_12_evidence_package.json
- review_repo
- ComputationalReviewVIP
- section_ref
- wiki_page:computationalreviewvip-12-computational-models
- source_kind
- review_finding
- source_path
- evidence/section_12_evidence_package.json
- study_system
- rate/spiking microcircuit model + EEG comparison
- section_title
- Computational Models of VIP Circuit Function
- evidence_summary
- NMDA hypofunction parameter sweeps mapped onto interneuron synapses; gamma power increases when PV-NMDA reduced and VIP recruitment shifted.
- review_bundle_ref
- analysis_bundle:ab-2ce40c33e827
- replication_status
- replication_unknown
- review_package_ref
- analysis_bundle:ab-2ce40c33e827
- source_artifact_ref
- wiki_page:computationalreviewvip-12-computational-models
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_12_evidence_package.json
- commit_sha
- 95e761177f7d2ec565983d3307c14ec238f9677c
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP
Raw fields (5)
- raw_fields
{ "n": null, "id": "cluster_11_finding_10", "doi": "10.1371/journal.pcbi.1013118", "pmid": "40489551", "year": "2025", "claim": "Computational modeling of a PV–SST–VIP cortical circuit reproduces ketamine-induced gamma changes, attributing increased gamma to PV hypofunction modulated by VIP-driven disinhibition.", "pmcid": "PMC12204622", "title": "Computational modeling of ketamine-induced changes in gamma-band oscillations: The contribution of parvalbumin and somatostatin interneurons.", "authors": "Rademacher J, Grent-'t-Jong T, Rivolta D, Sauer A, Scheller B, Gonzalez-Burgos G, Metzner C, Uhlhaas PJ.", "journal": "PLoS computational biology", "cite_key": "Rademacher2025", "evidence": "NMDA hypofunction parameter sweeps mapped onto interneuron synapses; gamma power increases when PV-NMDA reduced and VIP recruitment shifted.", "effect_size": null, "text_access": "fulltext", "study_system": "rate/spiking microcircuit model + EEG comparison", "_source_cluster": "cluster_11_computational_models", "replication_status": "replication_unknown", "_source_cluster_index": 9, "claim_source_sentence": "Finally, vasoactive intestinal peptide-expressing (VIP+) interneurons, which mainly target other GABAergic interneurons, including the PV+ and SST+ subclasses [ 25 ], may promote the disinhibition of pyramidal cells thus modulating oscillatory activity.", "replication_evidence_dois": [], "effect_size_source_sentence": null }- source_refs
[ "paper:paper-1f9e2fd192d2" ]
- source_span
Finally, vasoactive intestinal peptide-expressing (VIP+) interneurons, which mainly target other GABAergic interneurons, including the PV+ and SST+ subclasses [ 25 ], may promote the disinhibition of pyramidal cells thus modulating oscillatory activity.
- evidence_refs
[ { "ref": "paper:paper-1f9e2fd192d2" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP" }