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- Live5/17/2026, 4:35:28 PM
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{ "scope": "mouse hippocampus development", "claim_text": "Hippocampal VIP+ interneurons (calretinin+ IS-cells, CCK-VIP basket cells) are CGE-derived, generated in a later neurogenic wave (E12–E16) than MGE-derived PV/SST cells (E9–E12), and preferentially localize to superficial CA1 layers—reflecting the developmental origin of cells that pace theta and gamma rhythms differently.", "raw_fields": { "n": null, "doi": "10.1523/jneurosci.0323-11.2011", "pmid": "", "year": 2011, "claim": "Hippocampal VIP+ interneurons (calretinin+ IS-cells, CCK-VIP basket cells) are CGE-derived, generated in a later neurogenic wave (E12–E16) than MGE-derived PV/SST cells (E9–E12), and preferentially localize to superficial CA1 layers—reflecting the developmental origin of cells that pace theta and gamma rhythms differently.", "pmcid": "", "title": "A Blueprint for the Spatiotemporal Origins of Mouse Hippocampal Interneuron Diversity", "authors": "", "journal": "", "cite_key": "Tricoire2011", "evidence": "Cre-driver lineage fate mapping (Nkx2-1, Dlx1-CreER) + slice electrophysiology + immunolabeling.", "cluster_id": "cluster_09_oscillations", "effect_size": "Two waves: MGE E9-E12, CGE E12-E16", "figure_data": [], "text_access": "abstract_only", "study_system": "mouse hippocampus development", "cited_by_count": 305, "_source_cluster": "cluster_09_oscillations", "replication_status": "independently_replicated", "_source_cluster_index": 32, "claim_source_sentence": "hippocampal interneurons are produced in two neurogenic waves between E9-E12 and E12-E16 from MGE and CGE, respectively, and invade the hippocampus by E14. In the mature hippocampus, CGE-derived interneurons primarily localize to superficial layers in strata lacunosum moleculare and deep radiatum, while MGE-derived interneurons readily populate all layers with preference for strata pyramidale and oriens.", "replication_evidence_dois": [ "10.3389/neuro.05.003.2007" ], "effect_size_source_sentence": "hippocampal interneurons are produced in two neurogenic waves between E9-E12 and E12-E16 from MGE and CGE, respectively" }, "section_id": "section_10", "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_10_evidence_package.json", "effect_size": "Two waves: MGE E9-E12, CGE E12-E16", "review_repo": "ComputationalReviewVIP", "section_ref": "wiki_page:computationalreviewvip-10-oscillatory-dynamics", "source_kind": "review_finding", "source_path": "evidence/section_10_evidence_package.json", "source_refs": [ "paper:paper-6cdec9b9ae1d" ], "source_span": "hippocampal interneurons are produced in two neurogenic waves between E9-E12 and E12-E16 from MGE and CGE, respectively, and invade the hippocampus by E14. In the mature hippocampus, CGE-derived interneurons primarily localize to superficial layers in strata lacunosum moleculare and deep radiatum, while MGE-derived interneurons readily populate all layers with preference for strata pyramidale and oriens.", "study_system": "mouse hippocampus development", "evidence_refs": [ { "ref": "paper:paper-6cdec9b9ae1d" } ], "section_title": "Oscillatory Dynamics and Temporal Coordination", "source_policy": { "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP" }, "evidence_summary": "Cre-driver lineage fate mapping (Nkx2-1, Dlx1-CreER) + slice electrophysiology + immunolabeling.", "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827", "replication_status": "independently_replicated", "review_package_ref": "analysis_bundle:ab-2ce40c33e827", "source_artifact_ref": "wiki_page:computationalreviewvip-10-oscillatory-dynamics", "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_10_evidence_package.json", "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c", "created_by": "persona-jerome-lecoq-gbo-neuroscience", "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP" }