Hippocampal VIP+ interneurons (calretinin+ IS-cells, CCK-VIP basket cells) are…

Hippocampal VIP+ interneurons (calretinin+ IS-cells, CCK-VIP basket cells) are CGE-derived, generated in a later neurogenic wave (E12–E16) than MGE-derived PV/SST cells (E9–E12), and preferentially localize to superficial CA1 layers—reflecting the developmental origin of cells that pace theta and gamma rhythms differently.

{
  "n": null,
  "doi": "10.1523/jneurosci.0323-11.2011",
  "pmid": "",
  "year": 2011,
  "claim": "Hippocampal VIP+ interneurons (calretinin+ IS-cells, CCK-VIP basket cells) are CGE-derived, generated in a later neurogenic wave (E12–E16) than MGE-derived PV/SST cells (E9–E12), and preferentially localize to superficial CA1 layers—reflecting the developmental origin of cells that pace theta and gamma rhythms differently.",
  "pmcid": "",
  "title": "A Blueprint for the Spatiotemporal Origins of Mouse Hippocampal Interneuron Diversity",
  "authors": "",
  "journal": "",
  "cite_key": "Tricoire2011",
  "evidence": "Cre-driver lineage fate mapping (Nkx2-1, Dlx1-CreER) + slice electrophysiology + immunolabeling.",
  "cluster_id": "cluster_09_oscillations",
  "effect_size": "Two waves: MGE E9-E12, CGE E12-E16",
  "figure_data": [],
  "text_access": "abstract_only",
  "study_system": "mouse hippocampus development",
  "cited_by_count": 305,
  "_source_cluster": "cluster_09_oscillations",
  "replication_status": "independently_replicated",
  "_source_cluster_index": 32,
  "claim_source_sentence": "hippocampal interneurons are produced in two neurogenic waves between E9-E12 and E12-E16 from MGE and CGE, respectively, and invade the hippocampus by E14. In the mature hippocampus, CGE-derived interneurons primarily localize to superficial layers in strata lacunosum moleculare and deep radiatum, while MGE-derived interneurons readily populate all layers with preference for strata pyramidale and oriens.",
  "replication_evidence_dois": [
    "10.3389/neuro.05.003.2007"
  ],
  "effect_size_source_sentence": "hippocampal interneurons are produced in two neurogenic waves between E9-E12 and E12-E16 from MGE and CGE, respectively"
}

[
  "paper:paper-6cdec9b9ae1d"
]

hippocampal interneurons are produced in two neurogenic waves between E9-E12 and E12-E16 from MGE and CGE, respectively, and invade the hippocampus by E14. In the mature hippocampus, CGE-derived interneurons primarily localize to superficial layers in strata lacunosum moleculare and deep radiatum, while MGE-derived interneurons readily populate all layers with preference for strata pyramidale and oriens.

[
  {
    "ref": "paper:paper-6cdec9b9ae1d"
  }
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}