Timing-dependent LTD at mouse visual cortex L5 pyramidal-to-pyramidal synapses…

Timing-dependent LTD at mouse visual cortex L5 pyramidal-to-pyramidal synapses depends on non-ionotropic presynaptic NMDA receptor signalling via JNK2/STX1a — it persists after channel-pore block with MK-801 but is abolished by presynaptic NMDAR deletion or JNK2 inhibition.

{
  "n": 0,
  "doi": "10.7554/elife.106284",
  "claim": "Timing-dependent LTD at mouse visual cortex L5 pyramidal-to-pyramidal synapses depends on non-ionotropic presynaptic NMDA receptor signalling via JNK2/STX1a — it persists after channel-pore block with MK-801 but is abolished by presynaptic NMDAR deletion or JNK2 inhibition.",
  "cite_key": "Thomazeau2025",
  "evidence": "tLTD at L5 PC→PC synapses survived MK-801 channel-pore block (unlike tLTP), was abolished by presynaptic but not postsynaptic NMDAR deletion, and was blocked by the JNK2 inhibitor SP600125 and by a pre-loaded JNK2-STX1a interaction peptide.",
  "effect_size": null,
  "text_access": "abstract_only",
  "study_system": "Juvenile mouse visual cortex L5 pyramidal-to-pyramidal synapses (acute slice paired recording)",
  "argument_role": "supporting",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "We conclude that neocortical L5 PC→PC tLTD relies on non-ionotropic preNMDAR signaling via JNK2/STX1a.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

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