Version history

{
  "scope": "mouse S1 L2/3 slice",
  "claim_text": "In L2/3 of mouse S1, both PV+ and VIP+ interneurons monosynaptically inhibit Martinotti (SST+) cells but with distinct properties: connection probability ~58% PV→MC vs ~35% VIP→MC; mean IPSC amplitude PV 456.55±43.22 pA vs VIP 275.70±46.59 pA; PV→MC inputs depress while VIP→MC inputs facilitate at high frequencies.",
  "raw_fields": {
    "n": 21,
    "doi": "10.1038/ncomms13664",
    "claim": "In L2/3 of mouse S1, both PV+ and VIP+ interneurons monosynaptically inhibit Martinotti (SST+) cells but with distinct properties: connection probability ~58% PV→MC vs ~35% VIP→MC; mean IPSC amplitude PV 456.55±43.22 pA vs VIP 275.70±46.59 pA; PV→MC inputs depress while VIP→MC inputs facilitate at high frequencies.",
    "title": null,
    "cite_key": "Walker2016",
    "evidence": "Optogenetic ChR2 activation + paired whole-cell recordings of PV→MC and VIP→MC pairs in L2/3 S1.",
    "effect_size": "Pcon: PV→MC 12/21 (58%), VIP→MC 11/31 (35%); IPSC amplitude PV 456.55±43.22 pA, VIP 275.70±46.59 pA; PV depressing, VIP facilitating at high freq.",
    "text_access": "fulltext",
    "study_system": "mouse S1 L2/3 slice",
    "_source_cluster": "cluster_05_synaptic_connectivity",
    "replication_status": "replicated",
    "_source_cluster_index": 23,
    "claim_source_sentence": "The connection probability was higher for PV cells (∼58%, 12/21) than for VIP cells (∼35%, 11/31) ( ).",
    "replication_evidence_dois": [
      "10.1038/nn.3446"
    ],
    "effect_size_source_sentence": "PV cells evoked multicomponent IPSC with apparently larger amplitudes (PV: 456.55±43.22 pA; VIP: 275.70±46.59 pA; mean±s.e.m.) ( )."
  },
  "section_id": "section_06",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_06_evidence_package.json",
  "effect_size": "Pcon: PV→MC 12/21 (58%), VIP→MC 11/31 (35%); IPSC amplitude PV 456.55±43.22 pA, VIP 275.70±46.59 pA; PV depressing, VIP facilitating at high freq.",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-06-synaptic-properties",
  "source_kind": "review_finding",
  "source_path": "evidence/section_06_evidence_package.json",
  "source_refs": [
    "paper:paper-e93955349823"
  ],
  "source_span": "The connection probability was higher for PV cells (∼58%, 12/21) than for VIP cells (∼35%, 11/31) ( ).",
  "study_system": "mouse S1 L2/3 slice",
  "evidence_refs": [
    {
      "ref": "paper:paper-e93955349823"
    }
  ],
  "section_title": "Synaptic Properties and Connectivity",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Optogenetic ChR2 activation + paired whole-cell recordings of PV→MC and VIP→MC pairs in L2/3 S1.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replicated",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-06-synaptic-properties",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_06_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}