Version history

{
  "scope": "mouse barrel cortex acute slices, VIP-Cre",
  "claim_text": "The irregular-spiking (IS) firing pattern of cortical VIP interneurons depends on KCNQ-mediated M-current — pharmacological block (linopirdine) converts IS VIP-INs to tonic firing while leaving continuous-adapting (CA) VIP-INs unchanged, identifying KCNQ5/M-current as the molecular substrate of the IS phenotype.",
  "raw_fields": {
    "n": null,
    "doi": "10.7554/elife.46846",
    "claim": "The irregular-spiking (IS) firing pattern of cortical VIP interneurons depends on KCNQ-mediated M-current — pharmacological block (linopirdine) converts IS VIP-INs to tonic firing while leaving continuous-adapting (CA) VIP-INs unchanged, identifying KCNQ5/M-current as the molecular substrate of the IS phenotype.",
    "title": null,
    "cite_key": "Goff2019",
    "evidence": "mouse barrel cortex slices, whole-cell patch from VIP-Cre x Ai14 mice; pharmacology (linopirdine 10 μM); current-clamp characterization of IS vs CA VIP-INs",
    "effect_size": "qualitative: linopirdine converts IS to tonic in IS VIP-INs; null effect in CA VIP-INs",
    "text_access": "fulltext",
    "study_system": "mouse barrel cortex acute slices, VIP-Cre",
    "_source_cluster": "cluster_04_intrinsic_electrophysiology",
    "replication_status": "replication_unknown",
    "_source_cluster_index": 5,
    "claim_source_sentence": "Blockade of M-current with the KCNQ channel inhibitor linopirdine converted IS VIP-INs to a tonic firing mode but had no effect on CA VIP-INs.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Blockade of M-current with the KCNQ channel inhibitor linopirdine converted IS VIP-INs to a tonic firing mode but had no effect on CA VIP-INs."
  },
  "section_id": "section_05",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json",
  "effect_size": "qualitative: linopirdine converts IS to tonic in IS VIP-INs; null effect in CA VIP-INs",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-05-electrophysiology",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-038d4952015c"
  ],
  "source_span": "Blockade of M-current with the KCNQ channel inhibitor linopirdine converted IS VIP-INs to a tonic firing mode but had no effect on CA VIP-INs.",
  "study_system": "mouse barrel cortex acute slices, VIP-Cre",
  "evidence_refs": [
    {
      "ref": "paper:paper-038d4952015c"
    }
  ],
  "section_title": "Intrinsic Electrophysiology",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "mouse barrel cortex slices, whole-cell patch from VIP-Cre x Ai14 mice; pharmacology (linopirdine 10 μM); current-clamp characterization of IS vs CA VIP-INs",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-05-electrophysiology",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}