- claim_text
The irregular-spiking (IS) firing pattern of cortical VIP interneurons depends on KCNQ-mediated M-current — pharmacological block (linopirdine) converts IS VIP-INs to tonic firing while leaving continuous-adapting (CA) VIP-INs unchanged, identifying KCNQ5/M-current as the molecular substrate of the IS phenotype.
- raw_fields
{
"n": null,
"doi": "10.7554/elife.46846",
"claim": "The irregular-spiking (IS) firing pattern of cortical VIP interneurons depends on KCNQ-mediated M-current — pharmacological block (linopirdine) converts IS VIP-INs to tonic firing while leaving continuous-adapting (CA) VIP-INs unchanged, identifying KCNQ5/M-current as the molecular substrate of the IS phenotype.",
"title": null,
"cite_key": "Goff2019",
"evidence": "mouse barrel cortex slices, whole-cell patch from VIP-Cre x Ai14 mice; pharmacology (linopirdine 10 μM); current-clamp characterization of IS vs CA VIP-INs",
"effect_size": "qualitative: linopirdine converts IS to tonic in IS VIP-INs; null effect in CA VIP-INs",
"text_access": "fulltext",
"study_system": "mouse barrel cortex acute slices, VIP-Cre",
"_source_cluster": "cluster_04_intrinsic_electrophysiology",
"replication_status": "replication_unknown",
"_source_cluster_index": 5,
"claim_source_sentence": "Blockade of M-current with the KCNQ channel inhibitor linopirdine converted IS VIP-INs to a tonic firing mode but had no effect on CA VIP-INs.",
"replication_evidence_dois": [],
"effect_size_source_sentence": "Blockade of M-current with the KCNQ channel inhibitor linopirdine converted IS VIP-INs to a tonic firing mode but had no effect on CA VIP-INs."
}- source_refs
[
"paper:paper-038d4952015c"
]
- evidence_refs
[
{
"ref": "paper:paper-038d4952015c"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}