Version history

{
  "scope": "Mouse hand/forelimb S1 and M1; channelrhodopsin slice mapping",
  "claim_text": "In the mouse hand/forelimb sensorimotor cortico-cortical loop, S1→M1 projections from L2/3 and L5A neurons preferentially excite L2/3 neurons in M1, which in turn drive corticospinal neurons.",
  "raw_fields": {
    "n": null,
    "doi": "10.7554/elife.66836",
    "claim": "In the mouse hand/forelimb sensorimotor cortico-cortical loop, S1→M1 projections from L2/3 and L5A neurons preferentially excite L2/3 neurons in M1, which in turn drive corticospinal neurons.",
    "cite_key": "Yamawaki2021",
    "evidence": "Channelrhodopsin-assisted circuit mapping and slice electrophysiology of identified cell types along the cuneate→VPL→S1→M1→corticospinal pathway in mouse.",
    "effect_size": "Lemnisco-cortical disynaptic cuneate→VPL→S1 excites mainly L4 neurons; cortico-cortical S1→M1 L2/3 + L5A → M1 L2/3 → corticospinal (qualitative).",
    "text_access": "abstract_only",
    "study_system": "Mouse hand/forelimb S1 and M1; channelrhodopsin slice mapping",
    "argument_role": "supporting",
    "replication_status": "single-study",
    "claim_source_sentence": "In the corticocortical leg, S1→M1 connections from L2/3 and L5A neurons mainly excited downstream L2/3 neurons, which excite corticospinal neurons.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "In the lemnisco-cortical leg, disynaptic cuneate→VPL→S1 connections excited mainly layer (L) 4 neurons."
  },
  "section_id": "section_08",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_08_evidence_package.json",
  "effect_size": "Lemnisco-cortical disynaptic cuneate→VPL→S1 excites mainly L4 neurons; cortico-cortical S1→M1 L2/3 + L5A → M1 L2/3 → corticospinal (qualitative).",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-08-cross-areal",
  "source_kind": "review_finding",
  "source_path": "evidence/section_08_evidence_package.json",
  "source_refs": [
    "paper:paper-15b98c6c015d"
  ],
  "source_span": "In the corticocortical leg, S1→M1 connections from L2/3 and L5A neurons mainly excited downstream L2/3 neurons, which excite corticospinal neurons.",
  "study_system": "Mouse hand/forelimb S1 and M1; channelrhodopsin slice mapping",
  "evidence_refs": [
    {
      "ref": "paper:paper-15b98c6c015d"
    }
  ],
  "section_title": "8. Cross-areal mouse cortico-cortical excitatory connectivity — hierarchical feedforward and feedback as recurrent loops at the network level; Allen Mouse Connectivity Atlas anchored views",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Channelrhodopsin-assisted circuit mapping and slice electrophysiology of identified cell types along the cuneate→VPL→S1→M1→corticospinal pathway in mouse.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "single-study",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-08-cross-areal",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_08_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}