In the mouse hand/forelimb sensorimotor cortico-cortical loop, S1→M1 projection…

Details

scope: Mouse hand/forelimb S1 and M1; channelrhodopsin slice mapping
claim_text: In the mouse hand/forelimb sensorimotor cortico-cortical loop, S1→M1 projections from L2/3 and L5A neurons preferentially excite L2/3 neurons in M1, which in turn drive corticospinal neurons.
section_id: section_08
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_08_evidence_package.json
effect_size: Lemnisco-cortical disynaptic cuneate→VPL→S1 excites mainly L4 neurons; cortico-cortical S1→M1 L2/3 + L5A → M1 L2/3 → corticospinal (qualitative).
review_repo: ComputationalReviewRecurrence
section_ref: wiki_page:computationalreviewrecurrence-08-cross-areal
source_kind: review_finding
source_path: evidence/section_08_evidence_package.json
source_span: In the corticocortical leg, S1→M1 connections from L2/3 and L5A neurons mainly excited downstream L2/3 neurons, which excite corticospinal neurons.
study_system: Mouse hand/forelimb S1 and M1; channelrhodopsin slice mapping
section_title: 8. Cross-areal mouse cortico-cortical excitatory connectivity — hierarchical feedforward and feedback as recurrent loops at the network level; Allen Mouse Connectivity Atlas anchored views
evidence_summary: Channelrhodopsin-assisted circuit mapping and slice electrophysiology of identified cell types along the cuneate→VPL→S1→M1→corticospinal pathway in mouse.
review_bundle_ref: analysis_bundle:ab-d9c479db9be9
replication_status: single-study
review_package_ref: analysis_bundle:ab-d9c479db9be9
source_artifact_ref: wiki_page:computationalreviewrecurrence-08-cross-areal
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_08_evidence_package.json
commit_sha: 79ce062d54a924ce05953ec90aa9d26044d2b48f
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence

Raw fields (4)

raw_fields

{
  "n": null,
  "doi": "10.7554/elife.66836",
  "claim": "In the mouse hand/forelimb sensorimotor cortico-cortical loop, S1→M1 projections from L2/3 and L5A neurons preferentially excite L2/3 neurons in M1, which in turn drive corticospinal neurons.",
  "cite_key": "Yamawaki2021",
  "evidence": "Channelrhodopsin-assisted circuit mapping and slice electrophysiology of identified cell types along the cuneate→VPL→S1→M1→corticospinal pathway in mouse.",
  "effect_size": "Lemnisco-cortical disynaptic cuneate→VPL→S1 excites mainly L4 neurons; cortico-cortical S1→M1 L2/3 + L5A → M1 L2/3 → corticospinal (qualitative).",
  "text_access": "abstract_only",
  "study_system": "Mouse hand/forelimb S1 and M1; channelrhodopsin slice mapping",
  "argument_role": "supporting",
  "replication_status": "single-study",
  "claim_source_sentence": "In the corticocortical leg, S1&#x2192;M1 connections from L2/3 and L5A neurons mainly excited downstream L2/3 neurons, which excite corticospinal neurons.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "In the lemnisco-cortical leg, disynaptic cuneate&#x2192;VPL&#x2192;S1 connections excited mainly layer (L) 4 neurons."
}

source_refs

[
  "paper:paper-15b98c6c015d"
]

evidence_refs

[
  {
    "ref": "paper:paper-15b98c6c015d"
  }
]

source_policy

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}

In the mouse hand/forelimb sensorimotor cortico-cortical loop, S1→M1 projection…

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