Version history

{
  "scope": "Mouse motor cortex L2/3 pyramidal neurons during motor learning (in vivo two-photon + EM)",
  "claim_text": "Motor-learning-induced new dendritic spines in mouse M1 form near functionally clustered, task-related pre-existing spines and survive based on co-activity with their neighbours, producing functional synaptic clusters that signal the learned movement.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1038/s41593-022-01086-6",
    "claim": "Motor-learning-induced new dendritic spines in mouse M1 form near functionally clustered, task-related pre-existing spines and survive based on co-activity with their neighbours, producing functional synaptic clusters that signal the learned movement.",
    "cite_key": "Hedrick2022",
    "evidence": "In vivo two-photon imaging plus correlated EM in motor cortex during learning showed that potentiation of clustered active spines triggered local filopodial outgrowth; co-activity-selected new spines synapsed with previously unrepresented axons and formed locally coherent functional clusters.",
    "effect_size": null,
    "text_access": "abstract_only",
    "study_system": "Mouse motor cortex L2/3 pyramidal neurons during motor learning (in vivo two-photon + EM)",
    "argument_role": "supporting",
    "replication_status": "replication_unknown",
    "claim_source_sentence": "Specifically, our data indicate that the formation of new spines during learning is guided by the potentiation of functionally clustered preexisting spines exhibiting task-related activity during earlier sessions of learning.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
  },
  "section_id": "section_12",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_12_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-12-plasticity",
  "source_kind": "review_finding",
  "source_path": "evidence/section_12_evidence_package.json",
  "source_refs": [
    "paper:paper-c45090fcfe26"
  ],
  "source_span": "Specifically, our data indicate that the formation of new spines during learning is guided by the potentiation of functionally clustered preexisting spines exhibiting task-related activity during earlier sessions of learning.",
  "study_system": "Mouse motor cortex L2/3 pyramidal neurons during motor learning (in vivo two-photon + EM)",
  "evidence_refs": [
    {
      "ref": "paper:paper-c45090fcfe26"
    }
  ],
  "section_title": "12. Plasticity at E→E synapses in mouse — Hebbian, STDP, behavioural-time-scale plasticity; how plasticity shapes the recurrent matrix during learning",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "In vivo two-photon imaging plus correlated EM in motor cortex during learning showed that potentiation of clustered active spines triggered local filopodial outgrowth; co-activity-selected new spines synapsed with previously unrepresented axons and formed locally coherent functional clusters.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-12-plasticity",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_12_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}