Motor-learning-induced new dendritic spines in mouse M1 form near functionally…

Motor-learning-induced new dendritic spines in mouse M1 form near functionally clustered, task-related pre-existing spines and survive based on co-activity with their neighbours, producing functional synaptic clusters that signal the learned movement.

{
  "n": 0,
  "doi": "10.1038/s41593-022-01086-6",
  "claim": "Motor-learning-induced new dendritic spines in mouse M1 form near functionally clustered, task-related pre-existing spines and survive based on co-activity with their neighbours, producing functional synaptic clusters that signal the learned movement.",
  "cite_key": "Hedrick2022",
  "evidence": "In vivo two-photon imaging plus correlated EM in motor cortex during learning showed that potentiation of clustered active spines triggered local filopodial outgrowth; co-activity-selected new spines synapsed with previously unrepresented axons and formed locally coherent functional clusters.",
  "effect_size": null,
  "text_access": "abstract_only",
  "study_system": "Mouse motor cortex L2/3 pyramidal neurons during motor learning (in vivo two-photon + EM)",
  "argument_role": "supporting",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "Specifically, our data indicate that the formation of new spines during learning is guided by the potentiation of functionally clustered preexisting spines exhibiting task-related activity during earlier sessions of learning.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

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In vivo two-photon imaging plus correlated EM in motor cortex during learning showed that potentiation of clustered active spines triggered local filopodial outgrowth; co-activity-selected new spines synapsed with previously unrepresented axons and formed locally coherent functional clusters.