Version history

{
  "scope": "mouse MGE, slice culture, Nkx2.1-/-",
  "claim_text": "In the medial ganglionic eminence, NKX2.1 specifies cortical interneuron fate by directly activating Lhx6 expression; rescue experiments in Nkx2.1-/- slice cultures show that re-introduction of Nkx2.1 restores Lhx6 expression and PV/SST-fated interneuron specification — establishing the NKX2.1 → Lhx6 axis that distinguishes MGE-lineage from CGE-lineage interneuron identity.",
  "raw_fields": {
    "n": null,
    "doi": "10.1242/dev.015123",
    "claim": "In the medial ganglionic eminence, NKX2.1 specifies cortical interneuron fate by directly activating Lhx6 expression; rescue experiments in Nkx2.1-/- slice cultures show that re-introduction of Nkx2.1 restores Lhx6 expression and PV/SST-fated interneuron specification — establishing the NKX2.1 → Lhx6 axis that distinguishes MGE-lineage from CGE-lineage interneuron identity.",
    "title": null,
    "cite_key": "Du2008",
    "evidence": "Abstract: Nkx2.1 cDNA rescue in Nkx2.1-/- slice cultures and ChIP/in vivo expression analyses.",
    "effect_size": null,
    "text_access": "abstract_only",
    "study_system": "mouse MGE, slice culture, Nkx2.1-/-",
    "_source_cluster": "cluster_02_development_lineage",
    "replication_status": "replicated",
    "_source_cluster_index": 39,
    "claim_source_sentence": "We find that electroporation of Nkx2.1 cDNA into the ventral telencephalon of slice cultures from Nkx2.1-/- mouse embryos, followed by transplantation, rescues the differentiation of Lhx6-expressing interneurons.",
    "replication_evidence_dois": [
      "10.1016/j.neuron.2014.02.030"
    ],
    "effect_size_source_sentence": null
  },
  "section_id": "section_03",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-03-development",
  "source_kind": "review_finding",
  "source_path": "evidence/section_03_evidence_package.json",
  "source_refs": [
    "paper:paper-a9cd8f097456"
  ],
  "source_span": "We find that electroporation of Nkx2.1 cDNA into the ventral telencephalon of slice cultures from Nkx2.1-/- mouse embryos, followed by transplantation, rescues the differentiation of Lhx6-expressing interneurons.",
  "study_system": "mouse MGE, slice culture, Nkx2.1-/-",
  "evidence_refs": [
    {
      "ref": "paper:paper-a9cd8f097456"
    }
  ],
  "section_title": "Developmental Origins and Postnatal Maturation",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Abstract: Nkx2.1 cDNA rescue in Nkx2.1-/- slice cultures and ChIP/in vivo expression analyses.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replicated",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-03-development",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}