In the medial ganglionic eminence, NKX2.1 specifies cortical interneuron fate b…

In the medial ganglionic eminence, NKX2.1 specifies cortical interneuron fate by directly activating Lhx6 expression; rescue experiments in Nkx2.1-/- slice cultures show that re-introduction of Nkx2.1 restores Lhx6 expression and PV/SST-fated interneuron specification — establishing the NKX2.1 → Lhx6 axis that distinguishes MGE-lineage from CGE-lineage interneuron identity.

{
  "n": null,
  "doi": "10.1242/dev.015123",
  "claim": "In the medial ganglionic eminence, NKX2.1 specifies cortical interneuron fate by directly activating Lhx6 expression; rescue experiments in Nkx2.1-/- slice cultures show that re-introduction of Nkx2.1 restores Lhx6 expression and PV/SST-fated interneuron specification — establishing the NKX2.1 → Lhx6 axis that distinguishes MGE-lineage from CGE-lineage interneuron identity.",
  "title": null,
  "cite_key": "Du2008",
  "evidence": "Abstract: Nkx2.1 cDNA rescue in Nkx2.1-/- slice cultures and ChIP/in vivo expression analyses.",
  "effect_size": null,
  "text_access": "abstract_only",
  "study_system": "mouse MGE, slice culture, Nkx2.1-/-",
  "_source_cluster": "cluster_02_development_lineage",
  "replication_status": "replicated",
  "_source_cluster_index": 39,
  "claim_source_sentence": "We find that electroporation of Nkx2.1 cDNA into the ventral telencephalon of slice cultures from Nkx2.1-/- mouse embryos, followed by transplantation, rescues the differentiation of Lhx6-expressing interneurons.",
  "replication_evidence_dois": [
    "10.1016/j.neuron.2014.02.030"
  ],
  "effect_size_source_sentence": null
}

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