Version history

{
  "scope": "vip-interneurons",
  "claim_text": "In human telencephalon at 8–12 post-conceptional weeks, COUP-TFI shows a ventro-posterior to anterior gradient and is co-expressed with SP8 in dorsal sensory neocortex; COUP-TFI/COUP-TFII co-expression defines ventral temporal cortex/hippocampus, indicating distinct human-specific TF logic for arealization and GABAergic specification.",
  "raw_fields": {
    "n": null,
    "doi": "10.1093/cercor/bhx185",
    "year": "2017",
    "claim": "In human telencephalon at 8–12 post-conceptional weeks, COUP-TFI shows a ventro-posterior to anterior gradient and is co-expressed with SP8 in dorsal sensory neocortex; COUP-TFI/COUP-TFII co-expression defines ventral temporal cortex/hippocampus, indicating distinct human-specific TF logic for arealization and GABAergic specification.",
    "title": "The Transcription Factors COUP-TFI and COUP-TFII have Distinct Roles in Arealisation and GABAergic Interneuron Specification in the Early Human Fetal Telencephalon.",
    "authors": "Alzu'bi A, et al.",
    "journal": "Cerebral cortex (New York, N.Y. : 1991)",
    "cite_key": "Alzubi2017b",
    "effect_size": null,
    "text_access": "fulltext",
    "_source_cluster": "cluster_14_cge_lineage_context",
    "evidence_source": "fulltext",
    "cluster_relevance": "cge_lineage_context",
    "fulltext_available": true,
    "replication_status": null,
    "_source_cluster_index": 8,
    "claim_source_sentence": "In human telencephalon at 8-12 postconceptional weeks, ribonucleic acid quantitative sequencing and immunohistochemistry revealed cortical chicken ovalbumin upstream promotor-transcription factor 1 (COUP-TFI) expression in a high ventro-posterior to low anterior gradient except for raised immunoreactivity in the anterior ventral pallium. Unlike in mouse, COUP-TFI and SP8 were extensively co-expressed in dorsal sensory neocortex and dorsal hippocampus whereas COUPTFI/COUPTFII co-expression defined ventral temporal cortex and ventral hippocampus. In the ganglionic eminences (GEs) COUP-TFI immunoreactivity demarcated the proliferative zones of caudal GE (CGE), dorsal medial GE (MGE), MGE/lateral GE (LGE) boundary, and ventral LGE whereas COUP-TFII was limited to ventral CGE and the MGE/LGE boundary. Co-labeling with gamma amino butyric acidergic interneuron markers revealed that COUP-TFI was expressed in subpopulations of either MGE-derived (SOX6+) or CGE-derived (calretinin+/SP8+) interneurons. COUP-TFII was mainly confined to CGE-derived interneurons. Twice as many GAD67+ cortical cells co-labeled for COUP-TFI than for COUP-TFII. A fifth of COUP-TFI cells also co-expressed COUP-TFII"
  },
  "section_id": "section_03",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-03-development",
  "source_kind": "review_finding",
  "source_path": "evidence/section_03_evidence_package.json",
  "source_refs": [
    "paper:paper-87b5fbeec133"
  ],
  "source_span": "In human telencephalon at 8-12 postconceptional weeks, ribonucleic acid quantitative sequencing and immunohistochemistry revealed cortical chicken ovalbumin upstream promotor-transcription factor 1 (COUP-TFI) expression in a high ventro-posterior to low anterior gradient except for raised immunoreactivity in the anterior ventral pallium. Unlike in mouse, COUP-TFI and SP8 were extensively co-expressed in dorsal senso...",
  "study_system": null,
  "evidence_refs": [
    {
      "ref": "paper:paper-87b5fbeec133"
    }
  ],
  "section_title": "Developmental Origins and Postnatal Maturation",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": null,
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "unevaluated",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-03-development",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}