In human telencephalon at 8–12 post-conceptional weeks, COUP-TFI shows a ventro…

In human telencephalon at 8–12 post-conceptional weeks, COUP-TFI shows a ventro-posterior to anterior gradient and is co-expressed with SP8 in dorsal sensory neocortex; COUP-TFI/COUP-TFII co-expression defines ventral temporal cortex/hippocampus, indicating distinct human-specific TF logic for arealization and GABAergic specification.

{
  "n": null,
  "doi": "10.1093/cercor/bhx185",
  "year": "2017",
  "claim": "In human telencephalon at 8–12 post-conceptional weeks, COUP-TFI shows a ventro-posterior to anterior gradient and is co-expressed with SP8 in dorsal sensory neocortex; COUP-TFI/COUP-TFII co-expression defines ventral temporal cortex/hippocampus, indicating distinct human-specific TF logic for arealization and GABAergic specification.",
  "title": "The Transcription Factors COUP-TFI and COUP-TFII have Distinct Roles in Arealisation and GABAergic Interneuron Specification in the Early Human Fetal Telencephalon.",
  "authors": "Alzu'bi A, et al.",
  "journal": "Cerebral cortex (New York, N.Y. : 1991)",
  "cite_key": "Alzubi2017b",
  "effect_size": null,
  "text_access": "fulltext",
  "_source_cluster": "cluster_14_cge_lineage_context",
  "evidence_source": "fulltext",
  "cluster_relevance": "cge_lineage_context",
  "fulltext_available": true,
  "replication_status": null,
  "_source_cluster_index": 8,
  "claim_source_sentence": "In human telencephalon at 8-12 postconceptional weeks, ribonucleic acid quantitative sequencing and immunohistochemistry revealed cortical chicken ovalbumin upstream promotor-transcription factor 1 (COUP-TFI) expression in a high ventro-posterior to low anterior gradient except for raised immunoreactivity in the anterior ventral pallium. Unlike in mouse, COUP-TFI and SP8 were extensively co-expressed in dorsal sensory neocortex and dorsal hippocampus whereas COUPTFI/COUPTFII co-expression defined ventral temporal cortex and ventral hippocampus. In the ganglionic eminences (GEs) COUP-TFI immunoreactivity demarcated the proliferative zones of caudal GE (CGE), dorsal medial GE (MGE), MGE/lateral GE (LGE) boundary, and ventral LGE whereas COUP-TFII was limited to ventral CGE and the MGE/LGE boundary. Co-labeling with gamma amino butyric acidergic interneuron markers revealed that COUP-TFI was expressed in subpopulations of either MGE-derived (SOX6+) or CGE-derived (calretinin+/SP8+) interneurons. COUP-TFII was mainly confined to CGE-derived interneurons. Twice as many GAD67+ cortical cells co-labeled for COUP-TFI than for COUP-TFII. A fifth of COUP-TFI cells also co-expressed COUP-TFII"
}

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]

In human telencephalon at 8-12 postconceptional weeks, ribonucleic acid quantitative sequencing and immunohistochemistry revealed cortical chicken ovalbumin upstream promotor-transcription factor 1 (COUP-TFI) expression in a high ventro-posterior to low anterior gradient except for raised immunoreactivity in the anterior ventral pallium. Unlike in mouse, COUP-TFI and SP8 were extensively co-expressed in dorsal senso...

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