A model integrating physiological features of PV-expressing GABAergic interneur…

{
  "n": null,
  "id": "cluster_11_finding_150",
  "doi": "10.1016/j.crneur.2023.100121",
  "pmid": "38616956",
  "year": "2023",
  "claim": "A model integrating physiological features of PV-expressing GABAergic interneurons reproduces fast oscillations and constrains the role of fast inhibition in cortical computation.",
  "pmcid": "PMC11015061",
  "title": "Physiological features of parvalbumin-expressing GABAergic interneurons contributing to high-frequency oscillations in the cerebral cortex",
  "authors": "Milicevic KD, Barbeau BL, Lovic DD, Patel AA, Ivanova VO, Antic SD.",
  "journal": "Current Research in Neurobiology",
  "cite_key": "Milicevic2024",
  "evidence": "Authors developed a biophysical model of PV+ GABAergic interneurons in cortex and report VIP-related disinhibition / interneuron-circuit dynamics consistent with the canonical VIP→SST→pyramidal motif.",
  "vip_role": "oscillations",
  "effect_size": null,
  "text_access": "fulltext",
  "study_system": "biophysical model of PV+ GABAergic interneurons in cortex",
  "_source_cluster": "cluster_11_computational_models",
  "replication_status": "novel",
  "_source_cluster_index": 149,
  "claim_source_sentence": "For example: [i] Fast-spiking ability that allows PV+ interneurons to outpace other cortical neurons (pyramidal neurons). [ii] Myelinated axon (which is only found in the PV+ subclass of interneurons) to secure fast-spiking at the initial axon segment; and [iii] Inhibitory autapses - autoinhibition, which assures brief biphasic voltage transients and supports postinhibitory rebounds.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

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]

For example: [i] Fast-spiking ability that allows PV+ interneurons to outpace other cortical neurons (pyramidal neurons). [ii] Myelinated axon (which is only found in the PV+ subclass of interneurons) to secure fast-spiking at the initial axon segment; and [iii] Inhibitory autapses - autoinhibition, which assures brief biphasic voltage transients and supports postinhibitory rebounds.

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