Version history

{
  "scope": "biophysical model of PV+ GABAergic interneurons in cortex",
  "claim_text": "A model integrating physiological features of PV-expressing GABAergic interneurons reproduces fast oscillations and constrains the role of fast inhibition in cortical computation.",
  "raw_fields": {
    "n": null,
    "id": "cluster_11_finding_150",
    "doi": "10.1016/j.crneur.2023.100121",
    "pmid": "38616956",
    "year": "2023",
    "claim": "A model integrating physiological features of PV-expressing GABAergic interneurons reproduces fast oscillations and constrains the role of fast inhibition in cortical computation.",
    "pmcid": "PMC11015061",
    "title": "Physiological features of parvalbumin-expressing GABAergic interneurons contributing to high-frequency oscillations in the cerebral cortex",
    "authors": "Milicevic KD, Barbeau BL, Lovic DD, Patel AA, Ivanova VO, Antic SD.",
    "journal": "Current Research in Neurobiology",
    "cite_key": "Milicevic2024",
    "evidence": "Authors developed a biophysical model of PV+ GABAergic interneurons in cortex and report VIP-related disinhibition / interneuron-circuit dynamics consistent with the canonical VIP→SST→pyramidal motif.",
    "vip_role": "oscillations",
    "effect_size": null,
    "text_access": "fulltext",
    "study_system": "biophysical model of PV+ GABAergic interneurons in cortex",
    "_source_cluster": "cluster_11_computational_models",
    "replication_status": "novel",
    "_source_cluster_index": 149,
    "claim_source_sentence": "For example: [i] Fast-spiking ability that allows PV+ interneurons to outpace other cortical neurons (pyramidal neurons). [ii] Myelinated axon (which is only found in the PV+ subclass of interneurons) to secure fast-spiking at the initial axon segment; and [iii] Inhibitory autapses - autoinhibition, which assures brief biphasic voltage transients and supports postinhibitory rebounds.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
  },
  "section_id": "section_12",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_12_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-12-computational-models",
  "source_kind": "review_finding",
  "source_path": "evidence/section_12_evidence_package.json",
  "source_refs": [
    "paper:paper-dabe4bf98656"
  ],
  "source_span": "For example: [i] Fast-spiking ability that allows PV+ interneurons to outpace other cortical neurons (pyramidal neurons). [ii] Myelinated axon (which is only found in the PV+ subclass of interneurons) to secure fast-spiking at the initial axon segment; and [iii] Inhibitory autapses - autoinhibition, which assures brief biphasic voltage transients and supports postinhibitory rebounds.",
  "study_system": "biophysical model of PV+ GABAergic interneurons in cortex",
  "evidence_refs": [
    {
      "ref": "paper:paper-dabe4bf98656"
    }
  ],
  "section_title": "Computational Models of VIP Circuit Function",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Authors developed a biophysical model of PV+ GABAergic interneurons in cortex and report VIP-related disinhibition / interneuron-circuit dynamics consistent with the canonical VIP→SST→pyramidal motif.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "novel",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-12-computational-models",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_12_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}