Details
- scope
- mouse embryonic cortical interneuron progenitors (E13.5 through P20)
- claim_text
- The transcription factor Mef2c delineates early Pvalb-precursors and is essential for PV interneuron development, with conditional deletion leading to specific loss of PV interneurons.
- section_id
- section_02_evidence_package
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_02_evidence_package.json
- effect_size
- conditional deletion of Mef2c leads to specific loss of Pvalb-interneurons by P20 in cortical layers 2-6
- review_repo
- ComputationalReviewPV
- section_ref
- wiki_page:computationalreviewpv-02
- source_kind
- review_finding
- source_path
- evidence/section_02_evidence_package.json
- source_span
- Our analysis revealed that the ASD-associated transcription factor Mef2c delineates early Pvalb-precursors, and is essential for their development.
- study_system
- mouse embryonic cortical interneuron progenitors (E13.5 through P20)
- section_title
- Molecular Identity and Transcriptomic Taxonomy
- evidence_summary
- scRNA-seq across developmental time course showed Mef2c marks early PV precursors distinguishable from other MGE-derived types by E13.5.
- review_bundle_ref
- analysis_bundle:ab-e6261c8263e7
- replication_status
- independently_replicated
- review_package_ref
- analysis_bundle:ab-e6261c8263e7
- source_artifact_ref
- wiki_page:computationalreviewpv-02
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_02_evidence_package.json
- commit_sha
- df9fc7e8d455b084152c9d713558dae0013cef21
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV
Raw fields (4)
- raw_fields
{ "n": 0, "doi": "10.1038/nature25999", "claim": "The transcription factor Mef2c delineates early Pvalb-precursors and is essential for PV interneuron development, with conditional deletion leading to specific loss of PV interneurons.", "evidence": "scRNA-seq across developmental time course showed Mef2c marks early PV precursors distinguishable from other MGE-derived types by E13.5.", "effect_size": "conditional deletion of Mef2c leads to specific loss of Pvalb-interneurons by P20 in cortical layers 2-6", "text_access": "fulltext", "study_system": "mouse embryonic cortical interneuron progenitors (E13.5 through P20)", "replication_status": "independently_replicated", "claim_source_sentence": "Our analysis revealed that the ASD-associated transcription factor Mef2c delineates early Pvalb-precursors, and is essential for their development.", "replication_evidence_dois": [ "10.1038/s41586-021-03933-1" ], "effect_size_source_sentence": "conditional deletion of Mef2c in inhibitory neurons led to a specific loss of Pvalb-interneurons by P20 in cortical layers 2-6" }- source_refs
[ "paper:paper-c3e9fd7af6d3" ]
- evidence_refs
[ { "ref": "paper:paper-c3e9fd7af6d3" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV" }