Version history

{
  "scope": "mouse embryonic cortical interneuron progenitors (E13.5 through P20)",
  "claim_text": "The transcription factor Mef2c delineates early Pvalb-precursors and is essential for PV interneuron development, with conditional deletion leading to specific loss of PV interneurons.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1038/nature25999",
    "claim": "The transcription factor Mef2c delineates early Pvalb-precursors and is essential for PV interneuron development, with conditional deletion leading to specific loss of PV interneurons.",
    "evidence": "scRNA-seq across developmental time course showed Mef2c marks early PV precursors distinguishable from other MGE-derived types by E13.5.",
    "effect_size": "conditional deletion of Mef2c leads to specific loss of Pvalb-interneurons by P20 in cortical layers 2-6",
    "text_access": "fulltext",
    "study_system": "mouse embryonic cortical interneuron progenitors (E13.5 through P20)",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "Our analysis revealed that the ASD-associated transcription factor Mef2c delineates early Pvalb-precursors, and is essential for their development.",
    "replication_evidence_dois": [
      "10.1038/s41586-021-03933-1"
    ],
    "effect_size_source_sentence": "conditional deletion of Mef2c in inhibitory neurons led to a specific loss of Pvalb-interneurons by P20 in cortical layers 2-6"
  },
  "section_id": "section_02_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_02_evidence_package.json",
  "effect_size": "conditional deletion of Mef2c leads to specific loss of Pvalb-interneurons by P20 in cortical layers 2-6",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-02",
  "source_kind": "review_finding",
  "source_path": "evidence/section_02_evidence_package.json",
  "source_refs": [
    "paper:paper-c3e9fd7af6d3"
  ],
  "source_span": "Our analysis revealed that the ASD-associated transcription factor Mef2c delineates early Pvalb-precursors, and is essential for their development.",
  "study_system": "mouse embryonic cortical interneuron progenitors (E13.5 through P20)",
  "evidence_refs": [
    {
      "ref": "paper:paper-c3e9fd7af6d3"
    }
  ],
  "section_title": "Molecular Identity and Transcriptomic Taxonomy",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "evidence_summary": "scRNA-seq across developmental time course showed Mef2c marks early PV precursors distinguishable from other MGE-derived types by E13.5.",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-e6261c8263e7",
  "source_artifact_ref": "wiki_page:computationalreviewpv-02",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_02_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}