Version history

{
  "scope": "mouse, GE (E13.5 MGE / E14.5 CGE+LGE) → P10 cortex scRNA-seq",
  "claim_text": "Postmitotic ganglionic-eminence cells diverge into transcriptionally distinct precursor states corresponding to non-overlapping cardinal interneuron classes (Pvalb, Sst, Vip, Id2, Th, Nos1, Igfbp6), with Vip and Id2 cardinal markers (Vip/Synpr/Igf1, Reln/Mpped1/Id2) becoming statistically detectable by E18.5.",
  "raw_fields": {
    "n": null,
    "doi": "10.1038/nature25999",
    "claim": "Postmitotic ganglionic-eminence cells diverge into transcriptionally distinct precursor states corresponding to non-overlapping cardinal interneuron classes (Pvalb, Sst, Vip, Id2, Th, Nos1, Igfbp6), with Vip and Id2 cardinal markers (Vip/Synpr/Igf1, Reln/Mpped1/Id2) becoming statistically detectable by E18.5.",
    "title": null,
    "cite_key": "Mayer2018",
    "evidence": "Single-cell RNA-seq across mouse developmental timecourse, integrated MGE (E13.5)+CGE/LGE (E14.5) progenitors with postnatal P10 reference; cardinal-type segregation of Sst-Martinotti vs non-Martinotti, Vip bipolar vs multipolar visible by P10.",
    "effect_size": "7 cardinal classes; Vip-cardinal markers detectable by E18.5; clear bipolar vs multipolar Vip segregation by P10",
    "figure_data": [
      {
        "type": "developmental_marker_emergence",
        "unit": "embryonic day",
        "value": 18.5,
        "metric": "earliest E-stage with statistically conserved Vip cardinal markers",
        "source": "Mayer Fig.4 / Ext.Data Fig.7-9",
        "context": "Vip markers Vip/Synpr/Igf1; Id2 markers Reln/Mpped1/Id2"
      }
    ],
    "text_access": "fulltext",
    "study_system": "mouse, GE (E13.5 MGE / E14.5 CGE+LGE) → P10 cortex scRNA-seq",
    "_source_cluster": "cluster_02_development_lineage",
    "replication_status": "primary",
    "_source_cluster_index": 81,
    "claim_source_sentence": "These could be allocated into non-overlapping cardinal types of cortical interneurons (Pvalb, Sst, Vip, Id2, Th, Nos1, Igfbp6). A minority of E13.5 cells also mapped to Vip and Id2 subsets, but conserved transcriptomic markers did not pass statistical significance until E18.5 (E18.5 markers of Vip neurons: Vip , Synpr , Igf1 ; E18.5 markers of Id2 neurons: Reln , Mpped1, Id2 ).",
    "replication_evidence_dois": [
      "10.1038/nature25980"
    ],
    "effect_size_source_sentence": "Based on this alignment, P10 cells exhibited strong evidence of transcriptomic separation beyond cardinal types, ( Fig. 4B ), including clear segregation between Sst Martinotti versus non-Martinotti (X94), Vip bipolar versus multipolar, and Id2 neurogliaform versus non-neurogliaform interneuron subtypes ( Fig. 4E ; Extended Data Fig. 7 – 9 )."
  },
  "section_id": "section_03",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "effect_size": "7 cardinal classes; Vip-cardinal markers detectable by E18.5; clear bipolar vs multipolar Vip segregation by P10",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-03-development",
  "source_kind": "review_finding",
  "source_path": "evidence/section_03_evidence_package.json",
  "source_refs": [
    "paper:paper-c3e9fd7af6d3"
  ],
  "source_span": "These could be allocated into non-overlapping cardinal types of cortical interneurons (Pvalb, Sst, Vip, Id2, Th, Nos1, Igfbp6). A minority of E13.5 cells also mapped to Vip and Id2 subsets, but conserved transcriptomic markers did not pass statistical significance until E18.5 (E18.5 markers of Vip neurons: Vip , Synpr , Igf1 ; E18.5 markers of Id2 neurons: Reln , Mpped1, Id2 ).",
  "study_system": "mouse, GE (E13.5 MGE / E14.5 CGE+LGE) → P10 cortex scRNA-seq",
  "evidence_refs": [
    {
      "ref": "paper:paper-c3e9fd7af6d3"
    }
  ],
  "section_title": "Developmental Origins and Postnatal Maturation",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Single-cell RNA-seq across mouse developmental timecourse, integrated MGE (E13.5)+CGE/LGE (E14.5) progenitors with postnatal P10 reference; cardinal-type segregation of Sst-Martinotti vs non-Martinotti, Vip bipolar vs multipolar visible by P10.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "primary",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-03-development",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}