Postmitotic ganglionic-eminence cells diverge into transcriptionally distinct p…

Postmitotic ganglionic-eminence cells diverge into transcriptionally distinct precursor states corresponding to non-overlapping cardinal interneuron classes (Pvalb, Sst, Vip, Id2, Th, Nos1, Igfbp6), with Vip and Id2 cardinal markers (Vip/Synpr/Igf1, Reln/Mpped1/Id2) becoming statistically detectable by E18.5.

{
  "n": null,
  "doi": "10.1038/nature25999",
  "claim": "Postmitotic ganglionic-eminence cells diverge into transcriptionally distinct precursor states corresponding to non-overlapping cardinal interneuron classes (Pvalb, Sst, Vip, Id2, Th, Nos1, Igfbp6), with Vip and Id2 cardinal markers (Vip/Synpr/Igf1, Reln/Mpped1/Id2) becoming statistically detectable by E18.5.",
  "title": null,
  "cite_key": "Mayer2018",
  "evidence": "Single-cell RNA-seq across mouse developmental timecourse, integrated MGE (E13.5)+CGE/LGE (E14.5) progenitors with postnatal P10 reference; cardinal-type segregation of Sst-Martinotti vs non-Martinotti, Vip bipolar vs multipolar visible by P10.",
  "effect_size": "7 cardinal classes; Vip-cardinal markers detectable by E18.5; clear bipolar vs multipolar Vip segregation by P10",
  "figure_data": [
    {
      "type": "developmental_marker_emergence",
      "unit": "embryonic day",
      "value": 18.5,
      "metric": "earliest E-stage with statistically conserved Vip cardinal markers",
      "source": "Mayer Fig.4 / Ext.Data Fig.7-9",
      "context": "Vip markers Vip/Synpr/Igf1; Id2 markers Reln/Mpped1/Id2"
    }
  ],
  "text_access": "fulltext",
  "study_system": "mouse, GE (E13.5 MGE / E14.5 CGE+LGE) → P10 cortex scRNA-seq",
  "_source_cluster": "cluster_02_development_lineage",
  "replication_status": "primary",
  "_source_cluster_index": 81,
  "claim_source_sentence": "These could be allocated into non-overlapping cardinal types of cortical interneurons (Pvalb, Sst, Vip, Id2, Th, Nos1, Igfbp6). A minority of E13.5 cells also mapped to Vip and Id2 subsets, but conserved transcriptomic markers did not pass statistical significance until E18.5 (E18.5 markers of Vip neurons: Vip , Synpr , Igf1 ; E18.5 markers of Id2 neurons: Reln , Mpped1, Id2 ).",
  "replication_evidence_dois": [
    "10.1038/nature25980"
  ],
  "effect_size_source_sentence": "Based on this alignment, P10 cells exhibited strong evidence of transcriptomic separation beyond cardinal types, ( Fig. 4B ), including clear segregation between Sst Martinotti versus non-Martinotti (X94), Vip bipolar versus multipolar, and Id2 neurogliaform versus non-neurogliaform interneuron subtypes ( Fig. 4E ; Extended Data Fig. 7 – 9 )."
}

[
  "paper:paper-c3e9fd7af6d3"
]

These could be allocated into non-overlapping cardinal types of cortical interneurons (Pvalb, Sst, Vip, Id2, Th, Nos1, Igfbp6). A minority of E13.5 cells also mapped to Vip and Id2 subsets, but conserved transcriptomic markers did not pass statistical significance until E18.5 (E18.5 markers of Vip neurons: Vip , Synpr , Igf1 ; E18.5 markers of Id2 neurons: Reln , Mpped1, Id2 ).

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    "ref": "paper:paper-c3e9fd7af6d3"
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    "Local review repositories are read-only inputs.",
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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
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Single-cell RNA-seq across mouse developmental timecourse, integrated MGE (E13.5)+CGE/LGE (E14.5) progenitors with postnatal P10 reference; cardinal-type segregation of Sst-Martinotti vs non-Martinotti, Vip bipolar vs multipolar visible by P10.