Details
- scope
- mouse neocortical pyramidal cells and interneurons
- claim_text
- Patch-seq reveals a close link between electrophysiological characteristics, pharmacological responses, and RNA expression of neurotransmitter receptors and channels, distinguishing both established and novel neuronal subtypes.
- section_id
- section_05_evidence_package
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_05_evidence_package.json
- effect_size
- novel neuronal subtypes distinguished by combined electrophysiology-transcriptomics
- review_repo
- ComputationalReviewPV
- section_ref
- wiki_page:computationalreviewpv-05
- source_kind
- review_finding
- source_path
- evidence/section_05_evidence_package.json
- source_span
- We show that Patch-seq reveals a close link between electrophysiological characteristics, responses to acute chemical challenges and RNA expression of neurotransmitter receptors and channels.
- study_system
- mouse neocortical pyramidal cells and interneurons
- section_title
- Intrinsic Electrophysiology: The Fast-Spiking Phenotype and Its Variants
- evidence_summary
- Method combining whole-cell patch-clamp with full transcriptome sequencing from single neocortical neurons after electrophysiological recording in mouse brain slices.
- review_bundle_ref
- analysis_bundle:ab-e6261c8263e7
- replication_status
- independently_replicated
- review_package_ref
- analysis_bundle:ab-e6261c8263e7
- source_artifact_ref
- wiki_page:computationalreviewpv-05
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_05_evidence_package.json
- commit_sha
- df9fc7e8d455b084152c9d713558dae0013cef21
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV
Raw fields (4)
- raw_fields
{ "n": 0, "doi": "10.1038/nbt.3443", "claim": "Patch-seq reveals a close link between electrophysiological characteristics, pharmacological responses, and RNA expression of neurotransmitter receptors and channels, distinguishing both established and novel neuronal subtypes.", "evidence": "Method combining whole-cell patch-clamp with full transcriptome sequencing from single neocortical neurons after electrophysiological recording in mouse brain slices.", "effect_size": "novel neuronal subtypes distinguished by combined electrophysiology-transcriptomics", "text_access": "fulltext", "study_system": "mouse neocortical pyramidal cells and interneurons", "replication_status": "independently_replicated", "claim_source_sentence": "We show that Patch-seq reveals a close link between electrophysiological characteristics, responses to acute chemical challenges and RNA expression of neurotransmitter receptors and channels.", "replication_evidence_dois": [ "10.1016/j.cell.2020.09.057", "10.7554/elife.65482" ], "effect_size_source_sentence": "it distinguishes neuronal subpopulations that correspond to both well-established and, to our knowledge, hitherto undescribed neuronal subtypes." }- source_refs
[ "paper:paper-fd924ebdd0c4" ]
- evidence_refs
[ { "ref": "paper:paper-fd924ebdd0c4" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV" }