Version history

{
  "scope": "vip-interneurons",
  "claim_text": "A ~0.5–1% subpopulation of cortical VIP interneurons co-expresses choline acetyltransferase (ChAT-VIP) and locally releases acetylcholine that directly excites neighboring pyramidal and inhibitory neurons via fast cholinergic synaptic transmission, controlling attention behavior independently of basal-forebrain ACh.",
  "raw_fields": {
    "n": null,
    "doi": "10.1038/s41467-019-13244-9",
    "year": "2019",
    "claim": "A ~0.5–1% subpopulation of cortical VIP interneurons co-expresses choline acetyltransferase (ChAT-VIP) and locally releases acetylcholine that directly excites neighboring pyramidal and inhibitory neurons via fast cholinergic synaptic transmission, controlling attention behavior independently of basal-forebrain ACh.",
    "title": "Prefrontal cortical ChAT-VIP interneurons provide local excitation by cholinergic synaptic transmission and control attention",
    "journal": "",
    "species": "mouse",
    "cite_key": "Obermayer2019",
    "evidence": "Optogenetic stimulation in ChAT-Cre × VIP-Cre mice + paired recordings + behavior (5-CSRTT attention task).",
    "effect_size": "10–20% of postsynaptic neurons co-received both ACh and GABA from ChAT-VIP cells; ChAT-VIP silencing impaired attention performance.",
    "text_access": "fulltext",
    "_source_cluster": "cluster_13_neuromodulation",
    "replication_status": "supported",
    "_source_cluster_index": 12,
    "claim_source_sentence": "ChAT-VIP neurons directly excite neighbouring neurons in several layers through fast synaptic transmission of acetylcholine (ACh) in rodent medial prefrontal cortex (mPFC).",
    "replication_evidence_dois": [
      "10.7554/elife.57749",
      "10.1371/journal.pbio.3000613"
    ],
    "effect_size_source_sentence": "A fraction (10–20%) of postsynaptic neurons that received cholinergic input from ChAT-VIP interneurons also received GABAergic input from these neurons."
  },
  "section_id": "section_08",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_08_evidence_package.json",
  "effect_size": "10–20% of postsynaptic neurons co-received both ACh and GABA from ChAT-VIP cells; ChAT-VIP silencing impaired attention performance.",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-08-in-vivo-behavior",
  "source_kind": "review_finding",
  "source_path": "evidence/section_08_evidence_package.json",
  "source_refs": [
    "paper:paper-d66bdd18df1c"
  ],
  "source_span": "ChAT-VIP neurons directly excite neighbouring neurons in several layers through fast synaptic transmission of acetylcholine (ACh) in rodent medial prefrontal cortex (mPFC).",
  "study_system": null,
  "evidence_refs": [
    {
      "ref": "paper:paper-d66bdd18df1c"
    }
  ],
  "section_title": "In Vivo Function During Behavior",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Optogenetic stimulation in ChAT-Cre × VIP-Cre mice + paired recordings + behavior (5-CSRTT attention task).",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "supported",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-08-in-vivo-behavior",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_08_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}